Desvenlafaxine

Generic name: Desvenlafaxine
Drug class: Serotonin-norepinephrine reuptake inhibitors

Usage of Desvenlafaxine

Desvenlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant.

Desvenlafaxine is used to treat major depressive disorder.

Desvenlafaxine may also be used for purposes not listed in this medication guide.

Desvenlafaxine side effects

Get emergency medical help if you have signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself.

Desvenlafaxine may cause serious side effects. Call your doctor at once if you have:

a seizure;

easy bruising or bleeding (nosebleeds, bleeding gums), blood in your urine or stools, coughing up blood;

blurred vision, eye pain or swelling, or seeing halos around lights;

cough, chest discomfort, trouble breathing; or

low blood sodium--headache, confusion, problems with thinking or memory, weakness, feeling unsteady.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects of desvenlafaxine may include:

dizziness, drowsiness, anxiety;

increased sweating;

nausea, decreased appetite, constipation;

sleep problems (insomnia); or

decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Desvenlafaxine

You should not use desvenlafaxine if you are allergic to desvenlafaxine or venlafaxine (Effexor).

Do not use desvenlafaxine within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine. A dangerous drug interaction could occur.

Tell your doctor if you also use stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with desvenlafaxine could cause a serious condition called serotonin syndrome.

Tell your doctor if you have ever had:

heart disease, high blood pressure, high cholesterol, or a stroke;

bipolar disorder (manic depression);

depression, suicidal thoughts;

liver or kidney disease;

glaucoma;

seizures or epilepsy;

sexual problems;

lung or breathing problems;

a bleeding or blood clotting disorder; or

low levels of sodium in your blood.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

Taking this medicine during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop desvenlafaxine without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of desvenlafaxine on the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

Not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Desvenlafaxine

Usual Adult Dose for Depression:

50 mg orally once a day, with or without foodComments:-Doses of 10 to 400 mg/day were studied in clinical trials.-There is no evidence that doses greater than 50 mg per day provide additional benefit.-Side effects and discontinuations were more common at higher doses.-Efficacy in patients with major depressive disorder was established in 4 short-term and 2 maintenance studies.Use: Treatment of major depressive disorder (MDD)

Warnings

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.

Do not stop using desvenlafaxine without first asking your doctor.

What other drugs will affect Desvenlafaxine

Using desvenlafaxine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially a blood thinner (warfarin, Coumadin, Jantoven) or other medicine used to prevents blood clots.

Other drugs may affect desvenlafaxine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Disclaimer

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