Dexamethasone (EENT)
Drug class: Antineoplastic Agents
Usage of Dexamethasone (EENT)
Ophthalmic Inflammation
Symptomatic relief of corticosteroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe (e.g., allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitides).
Treatment of chronic anterior uveitis.
Treatment of corneal injury from chemical, radiation, or thermal burns or penetration of foreign bodies.
Bacterial Ophthalmic Infections
Used for anti-inflammatory properties in conjunction with appropriate anti-infective therapy in some bacterial infections of the eye; used in fixed combination with neomycin and polymyxin B sulfates or tobramycin when such combination therapy is indicated. If an ophthalmic corticosteroid is used in combination with an ophthalmic anti-infective, weigh benefits against risks. (See Infections under Cautions.)
Otic Inflammation
Symptomatic relief of corticosteroid-responsive inflammatory conditions of the ear canal (e.g., allergic otitis externa).
Bacterial Otic Infections
Used for anti-inflammatory properties in conjunction with ciprofloxacin for treatment of acute otitis externa and in pediatric patients with tympanostomy tubes for acute otitis media.
Used to reduce edema and inflammation in select cases of purulent and nonpurulent infective otitis externa.
If a corticosteroid is used alone or in combination with an otic anti-infective, weigh benefits against risks. (See Infections under Cautions.)
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- Betaxolol (EENT)
- Betaxolol (Systemic)
- Bexarotene (Systemic)
- Bismuth Salts
- Botulism Antitoxin (Equine)
- Brimonidine (EENT)
- Brivaracetam
- Brivaracetam
- Brolucizumab
- Brompheniramine
- Budesonide (EENT)
- Budesonide (Systemic, Oral Inhalation)
- Bulk-Forming Laxatives
- Bupivacaine (Local)
- BuPROPion (Systemic)
- Buspar
- Buspar Dividose
- Buspirone
- Butoconazole
- Cabotegravir (Systemic)
- Caffeine/Caffeine and Sodium Benzoate
- Calcitonin
- Calcium oxybate, magnesium oxybate, potassium oxybate, and sodium oxybate
- Calcium Salts
- Calcium, magnesium, potassium, and sodium oxybates
- Candida Albicans Skin Test Antigen
- Cantharidin (Topical)
- Capmatinib (Systemic)
- Carbachol
- Carbamide Peroxide
- Carbamide Peroxide
- Carmustine
- Castor Oil
- Catapres
- Catapres-TTS
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- Catapres-TTS-3
- Ceftolozane/Tazobactam (Systemic)
- Cefuroxime
- Centruroides Immune F(ab′)2
- Cetirizine (EENT)
- Charcoal, Activated
- Chloramphenicol
- Chlorhexidine (EENT)
- Chlorhexidine (EENT)
- Cholera Vaccine Live Oral
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- Hydroquinone
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- Influenza Virus Vaccine Inactivated
- Inotuzumab
- Insulin Human
- Interferon Alfa
- Interferon Beta
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- Intermezzo
- Intuniv
- Iodoquinol (Topical)
- Iodoquinol (Topical)
- Ipratropium (EENT)
- Ipratropium (EENT)
- Ipratropium (Systemic, Oral Inhalation)
- Ismelin
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- Ivermectin (Systemic)
- Ivermectin (Topical)
- Ixazomib Citrate (Systemic)
- Japanese Encephalitis Vaccine
- Kapvay
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- Ketorolac (EENT)
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- Ketotifen
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- Lecanemab
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- Leniolisib
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- Poractant Alfa
- Posaconazole
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How to use Dexamethasone (EENT)
Administration
Apply topically to the eye or ear.
Ophthalmic Administration
Apply topically to the eye as an ophthalmic ointment, solution, or suspension.
Not for injection.
Shake suspension well prior to each use.
Avoid contamination of preparation container.
Do not administer solutions or suspensions containing benzalkonium chloride while wearing soft contact lenses. Wait ≥15 minutes after instilling drops before inserting contact lenses. (See Advice to Patients.)
Otic Administration
Apply topically to the ear as an otic suspension or an ophthalmic solution.
Not for injection. Do not instill otic preparations into the eye.
May use Dexamethasone sodium phosphate ophthalmic solution in the ear.
Shake suspension well prior to each use.
To avoid dizziness that may result from instilling a cold preparation into the ear, warm the preparation by holding the bottle in the hands for 1–2 minutes prior to administration.
Clean and dry ear canal prior to administration; pH of otic preparations should be neutral or acidic.
Lie with the affected ear upward and instill drops. For pediatric patients with otitis media and tympanostomy tubes, pump the tragus 5 times to ease penetration of drops into the middle ear. For acute otitis externa, pull outer ear lobe upward and backward to facilitate entry of drug into ear canal.
Keep affected ear upward for ≥60 seconds following drug administration. If necessary, repeat procedure for the opposite ear.
Use otic corticosteroids sparingly to prevent an accumulation of excess debris in the ear canal.
Dosage
Commercially available alone or in fixed combination with anti-infectives; available as dexamethasone or dexamethasone sodium phosphate. Solution available as dexamethasone sodium phosphate; dosage expressed in terms of dexamethasone phosphate.
Pediatric Patients
Bacterial Ophthalmic InfectionsDuration of therapy depends on the type and severity of the disease and response to therapy. Do not discontinue prematurely.
When discontinuing therapy, gradually taper dosing frequency to avoid exacerbation of the disease.
Dexamethasone 0.1% and Tobramycin 0.3% Ophthalmic SuspensionChildren ≥2 years of age: Initial 24–48 hours, 1 or 2 drop(s) into the conjunctival sac of the affected eye(s) every 2 hours. Thereafter, 1 or 2 drops every 4–6 hours. Gradually reduce dosing frequency as infection improves.
Ophthalmic OintmentChildren ≥2 years of age: Apply a 1.25-cm ribbon into the conjunctival sac of the affected eye(s) up to 3 or 4 times daily.
Bacterial Otic Infections Acute Otitis Externa Otic Suspension (Dexamethasone 0.1% and Ciprofloxacin 0.3%)Children ≥6 months of age: 4 drops into the affected ear(s) twice daily for 7 days.
Acute Otitis Media Otic Suspension (Dexamethasone 0.1% and Ciprofloxacin 0.3%)Children ≥6 months of age with tympanostomy tubes: 4 drops into the affected ear(s) twice daily for 7 days.
Adults
Ophthalmic Inflammation and Bacterial InfectionsDuration of therapy depends on the type and severity of the disease and response to therapy. Do not discontinue prematurely.
When discontinuing therapy, gradually taper dosing frequency to avoid exacerbation of the disease.
Dexamethasone 0.1% Ophthalmic SuspensionFor mild inflammation: 1 or 2 drops into the conjunctival sac of the affected eye(s) up to 4–6 times daily.
For severe inflammation: 1 or 2 drops into the conjunctival sac of the affected eye(s) every hour. Taper dosing frequency as inflammation subsides.
Dexamethasone Sodium Phosphate 0.1% Ophthalmic SolutionInitially, 1 or 2 drops into the conjunctival sac of the affected eye(s) every hour during the day and every 2 hours during the night. When a favorable response is attained, decrease to 1 drop every 4 hours. May decrease to 1 drop 3 or 4 times daily to control symptoms.
Dexamethasone 0.1%, Neomycin 0.35%, and Polymyxin B Sulfates 10,000 units Ophthalmic SuspensionFor mild inflammation: 1 or 2 drop(s) into the conjunctival sac of the affected eye(s) up to 4–6 times daily.
For severe inflammation: 1 or 2 drops into the conjunctival sac of the affected eye(s) hourly. As inflammation subsides, gradually reduce dosing frequency to discontinue.
Ophthalmic OintmentApply a 1.25-cm ribbon into the conjunctival sac of the affected eye(s) up to 3 or 4 times daily.
Dexamethasone 0.1% and Tobramycin 0.3% Ophthalmic SuspensionInitial 24–48 hours, 1 or 2 drops into the conjunctival sac of the affected eye(s) every 2 hours; thereafter, 1 or 2 drops every 4 to 6 hours. Gradually reduce dosing frequency as infection improves.
Ophthalmic OintmentApply a 1.25-cm ribbon into the conjunctival sac of the affected eye(s) up to 3 or 4 times daily.
Otic Inflammation Dexamethasone Sodium Phosphate 0.1% Ophthalmic Solution OticInitially, 3 or 4 drops of the ophthalmic solution into the ear canal 2 or 3 times daily. May reduce dosing frequency as symptoms improve. Gradually taper the drug when it is discontinued.
Alternatively, a cotton wick saturated with the ophthalmic solution may be packed into the ear canal; keep the wick moist with the ophthalmic solution; remove saturated wick from ear after 12 to 24 hours. Repeat as necessary.
Duration of treatment may range from a few days to several weeks.
Bacterial Otic Infections: Acute Otitis Externa Dexamethasone 0.1% and Ciprofloxacin 0.3% Otic4 drops into the affected ear(s) twice daily for 7 days.
Special Populations
No special population dosage recommendations at this time.
Warnings
Contraindications
Warnings/Precautions
Warnings
Ocular EffectsRisk of glaucoma with possible damage to the optic nerve, defects in visual acuity and fields of vision, and posterior suBCapsular cataract formation with prolonged use of corticosteroids. Use with caution in patients with glaucoma because IOP may increase.
If used for ≥10 days, monitor IOP routinely even though monitoring may be difficult in children and uncooperative patients.
In conditions causing thinning of the cornea or sclera, perforations reported with use of topical corticosteroids.
Use of high-dose corticosteroids may delay healing. Use after cataract surgery may delay healing and increase incidence of bleb formation.
InfectionsProlonged use may suppress the host response and thus increase the risk of secondary ocular infections.
In acute purulent conditions of the eye or ear, corticosteroids may mask infection or enhance existing infection. (See Contraindications under Cautions.)
Herpes SimplexUse of corticosteroids in the treatment of herpes simplex infections other than epithelial herpes simplex keratitis, in which corticosteroids are contraindicated, requires great caution; periodic slit-lamp microscopy is essential.
General Precautions
Evaluation of Ocular ConditionInitial prescription or renewal of medication order beyond 8 g of 0.1% ointment or 20 mL of 0.1% suspension should be provided only after examination of the patient with the aid of magnification (e.g., slit lamp biomicroscopy, fluorescein staining where appropriate).
Fungal InfectionsLong-term local corticosteroid application associated with development of fungal infections of the cornea. Consider possibility of fungal infection in patients with persistent corneal ulceration who have been or are receiving corticosteroid therapy.
Corneal ReepithelializationUse of ophthalmic ointments may decrease rate of corneal reepithelialization.
Use of Fixed CombinationWhen used in fixed combination with ciprofloxacin, neomycin and polymyxin B sulfates, or tobramycin, consider the cautions, precautions, and contraindications associated with the concomitant agents.
Specific Populations
PregnancyCategory C.
LactationNot known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in milk.
Caution if used in nursing women.
Dexamethasone sodium phosphate ophthalmic solution and dexamethasone in fixed combination with ciprofloxacin otic suspension: Manufacturers recommend discontinuing nursing or the drug.
Pediatric UseSafety and efficacy of ophthalmic dexamethasone suspension or dexamethasone sodium phosphate solution not established.
Safety and efficacy of ophthalmic dexamethasone in fixed combination with neomycin and polymyxin B sulfates not established.
Safety and efficacy of ophthalmic dexamethasone in fixed combination with tobramycin not established in children <2 years of age.
Safety and efficacy of otic dexamethasone suspension in fixed combination with ciprofloxacin not established in infants <6 months of age.
Geriatric UseNo substantial differences in safety or efficacy relative to younger patients.
Common Adverse Effects
Ophthalmic administration: Elevated IOP, posterior subcapsular cataract formation, optic nerve damage, delayed wound healing.
Otic administration: Ear discomfort, ear pain, ear pruritus.
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