Diclofenac and misoprostol
Generic name: Diclofenac And Misoprostol
Brand names: Arthrotec
Drug class:
Nonsteroidal anti-inflammatory drugs
Usage of Diclofenac and misoprostol
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). Misoprostol reduces stomach acid and replaces protective substances in the stomach that are reduced by NSAIDs.
Diclofenac and misoprostol is a combination medicine used to treat osteoarthritis and rheumatoid arthritis in people at high risk for developing stomach or intestinal ulcers.
Diclofenac and misoprostol may also be used for purposes not listed in this medication guide.
Diclofenac and misoprostol side effects
Get emergency medical help if you have signs of an allergic reaction (sneezing, runny or stuffy nose, hives, wheezing or trouble breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Stop using diclofenac and misoprostol and seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.
diclofenac and misoprostol may cause serious side effects. Stop using diclofenac and misoprostol and call your doctor at once if you have:
Common side effects of diclofenac and misoprostol may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Diclofenac and misoprostol
Diclofenac can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use diclofenac and misoprostol just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Diclofenac may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using diclofenac and misoprostol, especially in older adults.
You should not use this medicine if you are allergic to diclofenac or misoprostol, or:
Tell your doctor if you have ever had:
Do not use this medicine if you are pregnant. Diclofenac and misoprostol can cause birth defects, miscarriage, premature labor, or rupture of the uterus. Use an effective form of birth control to prevent pregnancy while you are using this medicine. Tell your doctor right away if you become pregnant during treatment.
You will need to have a pregnancy test within 2 weeks before you start taking diclofenac and misoprostol. You may need to start taking this medicine only on the 2nd or 3rd day of a normal menstrual period.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
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How to use Diclofenac and misoprostol
Usual Adult Dose for Osteoarthritis:
One tablet (diclofenac 50 mg-misoprostol 200 mcg) orally 3 times a dayMaximum doses: diclofenac 150 mg/day; misoprostol 200 mcg/dose and 800 mcg/day Comments:-Monitor response to initial therapy and adjust dose and frequency to fit individual needs; consider titration of individual components if appropriate.-For patients who experience intolerance, diclofenac 75 mg-misoprostol 200 mcg or diclofenac 50 mg-misoprostol 200 mcg orally twice a day may be used, however these regimens are less effective in preventing ulcers.-For gastric ulcer prevention, misoprostol 200 mcg 3 times a day is therapeutically equivalent to 200 mcg 4 times a day and both are more protective than 200 mcg 2 times a day. -For duodenal ulcer prevention, misoprostol 200 mcg 4 times a day is more protective than 200 mcg 2 or 3 times a day, but may not be well tolerated. Use: For the treatment of signs and symptoms of osteoarthritis in patients at high risk of developing nonsteroidal anti-inflammatory drug (NSAID) induced gastric and duodenal ulcers and their complications
Usual Adult Dose for Rheumatoid Arthritis:
One tablet (diclofenac 50 mg-misoprostol 200 mcg) orally 3 to 4 times a dayMaximum doses: diclofenac 225 mg/day; misoprostol 200 mcg/dose and 800 mcg/day Comments:-For patients who experience intolerance, diclofenac 75 mg-misoprostol 200 mcg or diclofenac 50 mg-misoprostol 200 mcg orally twice a day may be used, however these regimens are less effective in preventing ulcers.-Monitor response to initial therapy and adjust dose and frequency to fit individual needs; consider titration of individual components if appropriate.-For gastric ulcer prevention, misoprostol 200 mcg 3 times a day is therapeutically equivalent to 200 mcg 4 times a day and both are more protective than 200 mcg 2 times a day. -For duodenal ulcer prevention, misoprostol 200 mcg 4 times a day is more protective than 200 mcg 2 or 3 times a day, but may not be well tolerated. Use: For the treatment of signs and symptoms of rheumatoid arthritis in patients at high risk of developing NSAID induced gastric and duodenal ulcers and their complications
Warnings
Do not use if you are pregnant. Misoprostol can cause birth defects, miscarriage, premature labor, or rupture of the uterus. You must have a negative pregnancy test within 2 weeks before you start taking diclofenac and misoprostol. You may need to start taking this medicine only on the 2nd or 3rd day of a normal menstrual period. Use effective birth control while you are using diclofenac and misoprostol.
Diclofenac can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Diclofenac may also cause stomach or intestinal bleeding, which can be fatal.
What other drugs will affect Diclofenac and misoprostol
Ask your doctor before using this medicine if you take an antidepressant. Taking certain antidepressants with an NSAID may cause you to bruise or bleed easily.
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect diclofenac and misoprostol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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