Diclofenac (Intravenous)

Generic name: Diclofenac
Drug class: Nonsteroidal anti-inflammatory drugs

Usage of Diclofenac (Intravenous)

Diclofenac injection is a nonsteroidal anti-inflammatory drug (NSAID) used to treat adults with mild to moderate pain. It is used alone or given with other opioid (narcotic) pain medicines to treat adults with moderate to severe pain.

This medicine is to be given only by or under the direct supervision of your doctor.

Diclofenac (Intravenous) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

Abdominal or stomach pain, cramping, or burning

bloody or black, tarry stools

bloody urine

decreased frequency or amount of urine

diarrhea

heartburn or indigestion

increased thirst

loss of appetite

lower back or side pain

nausea or vomiting

severe stomach pain

swelling of the face, fingers, or lower legs

trouble breathing

unusual tiredness or weakness

vomiting of blood or material that looks like coffee grounds

weight gain

Incidence not known

Blistering, peeling, or loosening of the skin

chest pain or discomfort

confusion

difficulty with speaking

double vision

fever or chills

headache

inability to move the arms, legs, or facial muscles

inability to speak

pain or discomfort in the arms, jaw, back, or neck

red skin lesions

slow speech

sores or ulcers on the skin

sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Difficulty having a bowel movement (stool)

dizziness

pain at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Diclofenac (Intravenous)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of diclofenac injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of diclofenac injection in the elderly. However, elderly patients are more likely to have age-related kidney or stomach problems, which may require caution for patients receiving diclofenac injection.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Ketorolac

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

ABCiximab

Acenocoumarol

Amiloride

Amineptine

Amitriptyline

Amitriptylinoxide

Amoxapine

Anagrelide

Apixaban

Ardeparin

Argatroban

Aspirin

Bemetizide

Bemiparin

Bendroflumethiazide

Benzthiazide

Betamethasone

Betrixaban

Bivalirudin

Budesonide

Bumetanide

Cangrelor

Capecitabine

Ceritinib

Certoparin

Chlorothiazide

Chlorthalidone

Cilostazol

Citalopram

Clomipramine

Clopamide

Clopidogrel

Cortisone

Cyclopenthiazide

Cyclosporine

Cyclothiazide

Dabigatran Etexilate

Dalteparin

Danaparoid

Deferiprone

Deflazacort

Desipramine

Desirudin

Desmopressin

Desvenlafaxine

Dexamethasone

Dexketoprofen

Diazoxide

Dibenzepin

Diflunisal

Digoxin

Dipyridamole

Dipyrone

Dothiepin

Doxepin

Droxicam

Duloxetine

Edoxaban

Emtricitabine

Enoxaparin

Eplerenone

Epoprostenol

Eptifibatide

Escitalopram

Ethacrynic Acid

Etodolac

Etofenamate

Etoricoxib

Etozolin

Felbinac

Fenoprofen

Fepradinol

Feprazone

Feverfew

Floctafenine

Flufenamic Acid

Fluocortolone

Fluoxetine

Flurbiprofen

Fluvoxamine

Fondaparinux

Furosemide

Ginkgo

Gossypol

Heparin

Hydrochlorothiazide

Hydrocortisone

Hydroflumethiazide

Ibuprofen

Iloprost

Imipramine

Indapamide

Inotersen

Ketoprofen

Lepirudin

Levoketoconazole

Levomilnacipran

Lithium

Lofepramine

Lornoxicam

Loxoprofen

Lumiracoxib

Magnesium Salicylate

Mavacamten

Meadowsweet

Meclofenamate

Mefenamic Acid

Melitracen

Meloxicam

Melphalan

Mesalamine

Methotrexate

Methyclothiazide

Methylprednisolone

Metolazone

Milnacipran

Morniflumate

Nabumetone

Nadroparin

Naproxen

Nefazodone

Nepafenac

Niflumic Acid

Nimesulide

Nimesulide Beta Cyclodextrin

Nortriptyline

Olsalazine

Opipramol

Oxaprozin

Oxyphenbutazone

Paramethasone

Parecoxib

Parnaparin

Paroxetine

Pemetrexed

Pentosan Polysulfate Sodium

Pentoxifylline

Phenindione

Phenprocoumon

Phenylbutazone

Phenyl Salicylate

Piketoprofen

Piretanide

Piroxicam

Polythiazide

Potassium Citrate

Prasugrel

Prednisolone

Prednisone

Proglumetacin

Propyphenazone

Proquazone

Protein C

Protriptyline

Quinethazone

Reviparin

Rivaroxaban

Rofecoxib

Salicylamide

Salicylic Acid

Salsalate

Selexipag

Sertraline

Sibutramine

Sodium Salicylate

Sparsentan

Spironolactone

Sulfasalazine

Sulfinpyrazone

Sulindac

Sulodexide

Tacrolimus

Tenofovir Alafenamide

Tenofovir Disoproxil Fumarate

Tenoxicam

Tianeptine

Tiaprofenic Acid

Ticagrelor

Ticlopidine

Tinzaparin

Tirofiban

Tolfenamic Acid

Tolmetin

Torsemide

Trazodone

Treprostinil

Triamterene

Trichlormethiazide

Trimipramine

Trolamine Salicylate

Valdecoxib

Venlafaxine

Vilazodone

Vorapaxar

Vortioxetine

Warfarin

Xipamide

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acebutolol

Atenolol

Azilsartan

Azilsartan Medoxomil

Benazepril

Betaxolol

Bisoprolol

Candesartan

Captopril

Carteolol

Carvedilol

Celiprolol

Ciprofloxacin

Enalapril

Enalaprilat

Eprosartan

Esmolol

Fosinopril

Irbesartan

Labetalol

Levobunolol

Lisinopril

Losartan

Metipranolol

Metoprolol

Moexipril

Nadolol

Nebivolol

Olmesartan

Oxprenolol

Penbutolol

Perindopril

Pindolol

Propranolol

Quinapril

Ramipril

Sotalol

Spirapril

Telmisartan

Timolol

Trandolapril

Valsartan

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Relate drugs

How to use Diclofenac (Intravenous)

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins.

Drink extra fluids so you will pass more urine before receiving this medicine. This may help prevent kidney problems.

Warnings

It is very important that your doctor check you closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.

This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk.

This medicine may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, are over 60 years of age, are in poor health, or are using certain medicines (such as a steroid medicine or a blood thinner).

Check with your doctor right away if you have any symptoms of liver problems including dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, or yellowing of your skin or the whites of your eyes.

If you are rapidly gaining weight, having shortness of breath, chest pain, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor immediately. These may be symptoms of heart problems or your body keeping too much water.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur more often in patients who are allergic to aspirin or nonsteroidal antiinflammatory drugs (NSAIDs). Anaphylaxis can be life-threatening and requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, or fainting. Other signs may include changes in color of the skin of the face, very fast but irregular heartbeat or pulse, hive-like swellings on the skin, and puffiness or swelling of the eyelids or around the eyes. If these effects occur, get emergency help at once.

Serious skin reactions can occur during treatment with this medicine. Tell your doctor right away if you have any of the following symptoms while using this medicine: blistering, peeling, loosening of the skin, red skin lesions, sores or ulcers on the skin, or fever or chills.

It is important to tell your doctor if you are pregnant or planning to become pregnant before using this medicine. Using this medicine late in pregnancy can harm your unborn baby. Do not use this medicine during the latter part of a pregnancy unless your doctor tells you to.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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