Dimethyl fumarate

Generic name: Dimethyl Fumarate
Dosage form: oral delayed release capsule (-; 120 mg; 240 mg)
Drug class: Selective immunosuppressants

Usage of Dimethyl fumarate

Dimethyl fumarate is used to treat relapsing forms of multiple sclerosis in adults (including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease).

Dimethyl fumarate may also be used for purposes not listed in this medication guide.

Dimethyl fumarate side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Dimethyl fumarate may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly.

Also call your doctor at once if you have:

  • symptoms of herpes virus--flu-like symptoms, cold sores around your mouth, tingly or painful blistering rash, burning pain in your thigh or lower back;
  • low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough, trouble breathing; or
  • liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

    • Common side effects of dimethyl fumarate may include:

  • stomach pain, indigestion, nausea, vomiting, diarrhea;
  • redness, rash, itching; or
  • flushing (sudden warmth, redness, or tingly feeling).

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Dimethyl fumarate

    You should not use dimethyl fumarate if you have had a severe allergic reaction to dimethyl fumarate or diroximel fumarate (Vumerity).

    Tell your doctor if you have ever had:

  • an active infection; or
  • low white blood cell (WBC) counts.

    • Tell your doctor if you are pregnant or breastfeeding.

    If you are pregnant, your name may be listed on a pregnancy registry to track the effects of dimethyl fumarate on the baby.

    Dimethyl fumarate is not approved for use by anyone younger than 18 years old.

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    How to use Dimethyl fumarate

    Usual Adult Dose for Multiple Sclerosis:

    Initial dose: 120 mg orally twice a day for 7 daysMaintenance dose: 240 mg orally twice a dayUse: For the treatment of relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease

    Warnings

    Dimethyl fumarate may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly.

    What other drugs will affect Dimethyl fumarate

    Other drugs may affect dimethyl fumarate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

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