Disulfiram

Generic name: Disulfiram
Brand names: Antabuse
Dosage form: oral tablet
Drug class: Drugs used in alcohol dependence

Usage of Disulfiram

Disulfiram may be used to treat alcohol use disorder (also called chronic alcoholism) and works by blocking an enzyme that is involved in breaking down alcohol.

Combining disulfiram with alcohol produces very unpleasant side effects which can help keep you from drinking.

Disulfiram is not a cure for alcohol use disorder and other non-drug treatments, such as behavior modification, psychotherapy, and counseling support are needed in addition to disulfiram to give you the best possible chance to stop drinking.

Disulfiram was FDA approved in 1951.

Disulfiram side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Even small amounts of alcohol can produce unpleasant symptoms while disulfiram is in your body. These symptoms include:

flushing (warmth, redness, or tingly feeling);

sweating, increased thirst, swelling, rapid weight gain;

nausea, severe vomiting;

neck pain, throbbing headache, blurred vision;

chest pain, shortness of breath (even with mild exertion);

fast or pounding heartbeats or fluttering in your chest;

confusion, weakness, spinning sensation, feeling unsteady; or

a light-headed feeling, like you might pass out.

More severe symptoms may occur when disulfiram and large amounts of alcohol are used together, such as severe chest pain spreading to your jaw or shoulder, slow heart rate, weak pulse, seizure, fainting, weak or shallow breathing, or slow breathing (breathing may stop). A disulfiram-alcohol reaction can be fatal.

Disulfiram may cause serious side effects. Call your doctor at once if you have:

eye pain or sudden vision loss;

confusion, unusual thoughts or behavior; or

liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of disulfiram may include:

skin rash, acne;

mild headache, tired feeling;

impotence, loss of interest in sex; or

metallic or garlic-like taste in the mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Disulfiram

Do not take disulfiram if you have consumed alcohol within the past 12 hours. Do not drink alcohol while taking disulfiram and for up to 14 days after you stop taking disulfiram.

You should not use disulfiram if you are allergic to it, or if:

you have recently taken metronidazole (Flagyl) or paraldehyde; or

you have consumed any foods or products that contain alcohol (mouthwash, cough medicine, cooking wine or vinegar, certain desserts, and others).

To make sure disulfiram is safe for you, tell your doctor if you have:

liver or kidney disease;

heart disease, high blood pressure, history of heart attack or stroke;

underactive thyroid;

diabetes;

seizures or epilepsy;

head injury or brain damage;

a history of mental illness or psychosis;

an allergy to rubber; or

if you take phenytoin (Dilantin), tuberculosis medicine, or a blood thinner (warfarin, Coumadin, Jantoven).

FDA pregnancy category C. It is not known whether disulfiram will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while taking disulfiram.

It is not known whether disulfiram passes into breast milk or if it could harm a nursing baby and you should not breast-feed while taking it.

Do not give disulfiram to anyone under 18 years old without medical advice.

Relate drugs

How to use Disulfiram

Usual Adult Dose for Alcohol Dependence:

-Initial dose: 500 mg orally once a day (this dose is generally continued for the first 1 to 2 weeks) -Maintenance dose: 250 mg orally once a day (range: 125 mg to 500 mg once a day) Maximum dose: 500 mg once a day -Duration of therapy: Depending on the individual, therapy may last months or even years Comment: -Although usually taken in the morning, this drug may be dosed in the evening by patients who experience a sedative effect. Also, the dosage may be adjusted downward. Use: An alcohol deterrent in the treatment of carefully selected and cooperative patients with drinking problems; its use should be accompanied by appropriate supportive treatment.

Warnings

You should not use disulfiram if you have recently taken metronidazole or paraldehyde, or if you have consumed any foods or products that contain alcohol (mouthwash, cough medicine, cooking wine or vinegar, certain desserts, and others).

Do not take disulfiram if you have consumed alcohol within the past 12 hours. Do not drink alcohol while taking disulfiram, and for up to 14 days after you stop taking this medicine.

Disulfiram should never be given to a person without his or her knowledge of taking the medicine.

What other drugs will affect Disulfiram

Other drugs may interact with disulfiram, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Disclaimer

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