Dolasetron (Oral)

Generic name: Dolasetron
Drug class: 5HT3 receptor antagonists

Usage of Dolasetron (Oral)

Dolasetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation. Dolasetron works to block the signals to the brain that cause nausea and vomiting.

This medicine is available only with your doctor's prescription.

Dolasetron (Oral) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chest pain or discomfort

lightheadedness, dizziness, or fainting

slow or irregular heartbeat

unusual tiredness or weakness

Less common

Chills

decrease in the amount of urine

fast, pounding, or irregular heartbeat or pulse

fever

Rare

Agitation

black, tarry stools

bleeding gums

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine or stools

blurred vision

burning while urinating

changes in skin color

confusion

cough

delirium

depression

diarrhea

difficult or labored breathing

difficult or painful urination

difficulty with swallowing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

feeling of warmth

feeling uncoordinated

frequent urination

hallucinations

headache

hives or welts, itching, or skin rash

increased volume of pale, dilute urine

irritability

lethargy

muscle twitching

nausea

noisy breathing

numbness and tingling of the face, fingers, or toes

pain in the arms, legs, or lower back, especially pain in the calves or heels upon exertion

pain, tenderness, or swelling of the foot or leg

pale skin

pale, bluish-colored, or cold hands or feet

pinpoint red or purple spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid weight gain

red skin

rigid muscles

seizures

sweating

swelling of the face, ankles, or hands

tightness in the chest

tingling of the hands or feet

tremor

troubled breathing with exertion

unusual bleeding or bruising

unusual weight gain or loss

vomiting

weak or absent pulses in the legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Belching

heartburn

indigestion

pain

stomach discomfort, upset, or pain

Rare

Abnormal dreams

bad, unusual, or unpleasant (after) taste

bloating

bloody nose

change in taste

changes in vision

continuing ringing or buzzing or other unexplained noise in the ears

darkened urine

difficulty having a bowel movement (stool)

difficulty seeing at night

difficulty with moving

feeling of constant movement of self or surroundings

feeling of unreality

hearing loss

increased sensitivity of the eyes to sunlight

increased sweating

joint pain

loss of appetite

muscle aching or cramping

muscle pain or stiffness

pain or burning sensation at the injection site

pains in the stomach, side, or abdomen, possibly radiating to the back

redness of the face, neck, arms, and occasionally, upper chest

sensation of spinning

sense of detachment from self or body

shakiness and unsteady walk

shakiness in the legs, arms, hands, or feet

swollen joints

unsteadiness, trembling, or other problems with muscle control or coordination

weight loss

yellow eyes or skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Dolasetron (Oral)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of dolasetron in children 2 years of age and older. However, safety and efficacy have not been established in children younger than 2 years of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dolasetron in the elderly. However, elderly patients are more likely to have heart rhythm problems, which may require caution in patients receiving dolasetron.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Apomorphine

Bepridil

Cisapride

Dronedarone

Levoketoconazole

Levomethadyl

Mesoridazine

Pimozide

Piperaquine

Saquinavir

Sparfloxacin

Terfenadine

Thioridazine

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acecainide

Adagrasib

Ajmaline

Alfentanil

Alfuzosin

Almotriptan

Amineptine

Amiodarone

Amisulpride

Amitriptyline

Amitriptylinoxide

Amoxapine

Amphetamine

Anagrelide

Aprindine

Aripiprazole

Aripiprazole Lauroxil

Arsenic Trioxide

Asenapine

Astemizole

Atazanavir

Azimilide

Azithromycin

Benzhydrocodone

Benzphetamine

Bretylium

Brompheniramine

Buprenorphine

Buserelin

Buspirone

Butorphanol

Carbamazepine

Ceritinib

Chloral Hydrate

Chloroquine

Chlorpheniramine

Chlorpromazine

Ciprofloxacin

Citalopram

Clarithromycin

Clofazimine

Clomipramine

Clothiapine

Clozapine

Cocaine

Codeine

Crizotinib

Cyclobenzaprine

Dabrafenib

Dasatinib

Degarelix

Delamanid

Desipramine

Deslorelin

Desvenlafaxine

Deutetrabenazine

Dexmedetomidine

Dextroamphetamine

Dextromethorphan

Dibenzepin

Dihydrocodeine

Disopyramide

Dofetilide

Domperidone

Donepezil

Doxepin

Droperidol

Duloxetine

Efavirenz

Eletriptan

Encorafenib

Enflurane

Entrectinib

Erythromycin

Escitalopram

Etrasimod

Fenfluramine

Fentanyl

Fexinidazole

Fingolimod

Flecainide

Fluconazole

Fluoxetine

Fluvoxamine

Formoterol

Foscarnet

Fostemsavir

Frovatriptan

Furazolidone

Gatifloxacin

Gemifloxacin

Gepirone

Glasdegib

Gonadorelin

Goserelin

Granisetron

Halofantrine

Haloperidol

Halothane

Histrelin

Hydrocodone

Hydromorphone

Hydroquinidine

Hydroxyamphetamine

Hydroxychloroquine

Hydroxytryptophan

Hydroxyzine

Ibutilide

Iloperidone

Imipramine

Inotuzumab Ozogamicin

Iproniazid

Isocarboxazid

Isoflurane

Isradipine

Ivabradine

Ivosidenib

Ketoconazole

Lacosamide

Lapatinib

Lasmiditan

Lefamulin

Lenvatinib

Leuprolide

Levofloxacin

Levomilnacipran

Levorphanol

Lidoflazine

Linezolid

Lisdexamfetamine

Lithium

Lofepramine

Lofexidine

Lopinavir

Lorcainide

Lorcaserin

Lumefantrine

Macimorelin

Mefloquine

Melitracen

Meperidine

Metaxalone

Methadone

Methamphetamine

Methylene Blue

Metronidazole

Mifepristone

Milnacipran

Mirtazapine

Mobocertinib

Moclobemide

Morphine

Morphine Sulfate Liposome

Moxifloxacin

Nafarelin

Nalbuphine

Naratriptan

Nefazodone

Nilotinib

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Olanzapine

Ondansetron

Opipramol

Osilodrostat

Osimertinib

Oxaliplatin

Oxycodone

Oxymorphone

Ozanimod

Pacritinib

Paliperidone

Panobinostat

Paroxetine

Pasireotide

Pazopanib

Pentamidine

Pentazocine

Phenelzine

Phenobarbital

Pimavanserin

Pirmenol

Pitolisant

Ponesimod

Posaconazole

Prajmaline

Primidone

Probucol

Procainamide

Procarbazine

Prochlorperazine

Promethazine

Propafenone

Protriptyline

Quetiapine

Quinidine

Quinine

Quizartinib

Ranolazine

Rasagiline

Relugolix

Remifentanil

Ribociclib

Risperidone

Rizatriptan

Selegiline

Selpercatinib

Sematilide

Sertindole

Sertraline

Sevoflurane

Sibutramine

Siponimod

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sorafenib

Sotalol

Spiramycin

St John's Wort

Sufentanil

Sulfamethoxazole

Sulpiride

Sultopride

Sumatriptan

Sunitinib

Tacrolimus

Tapentadol

Tedisamil

Telavancin

Telithromycin

Tetrabenazine

Tianeptine

Toremifene

Tramadol

Tranylcypromine

Trazodone

Triclabendazole

Trifluoperazine

Trimethoprim

Trimipramine

Triptorelin

Tryptophan

Vandetanib

Vardenafil

Vemurafenib

Venlafaxine

Vilanterol

Vilazodone

Vinflunine

Voclosporin

Voriconazole

Vortioxetine

Zolmitriptan

Zotepine

Zuclopenthixol

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Relate drugs

How to use Dolasetron (Oral)

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

If your child cannot swallow the tablets, the injection solution can be mixed with apple or apple-grape juice and taken by mouth. The mixture may be stored for up to 2 hours at room temperature before use.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):

For prevention of nausea and vomiting after cancer medicines:

Adults—100 milligrams (mg) given within 1 hour before starting cancer treatment.

Children 2 to 16 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 1.8 milligrams (mg) per kilogram (kg) of body weight given within 1 hour before starting cancer treatment. However, the dose is usually not more than 100 mg.

Children younger than 2 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose of this medicine, and you feel nauseated or you vomit, take the missed dose as soon as possible.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.

This medicine can cause changes heart rhythms, such as conditions called QT, PR, and QRS prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you have a fast, pounding, or irregular heartbeats.

Dolasetron may cause a serious condition called serotonin syndrome if taken together with some medicines such as fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), a MAO inhibitor (such as methylene blue injection, Eldepryl®, Marplan®, Nardil®, Parnate®), medicine to treat migraine headaches, or medicine to treat depression (eg, fluoxetine, mirtazapine, paroxetine, Celexa®, Effexor®, Lexapro®, Paxil®, Zoloft®). Check with your doctor first before taking any other medicines with dolasetron.

Do not stop taking this medicine without checking first with your doctor. Your doctor may gradually reduce the amount you are using before stopping completely.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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