Dolutegravir and lamivudine

Generic name: Dolutegravir And Lamivudine
Brand names: Dovato
Dosage form: oral tablet (50 mg-300 mg)
Drug class: Antiviral combinations

Usage of Dolutegravir and lamivudine

Dolutegravir and lamivudine is a combination antiviral medicine used to treat human immunodeficiency virus (HIV), the virus that can cause the acquired immunodeficiency syndrome (AIDS). dolutegravir and lamivudine is not a cure for HIV or AIDS.

Dolutegravir and lamivudine is sometimes used in adults who have never been treated with other HIV medications.

Dolutegravir and lamivudine is also used to replace other HIV medications in adults with suppressed viral loads. Your doctor will determine which medication is best for you.

Dolutegravir and lamivudine may also be used for purposes not listed in this medication guide.

Dolutegravir and lamivudine side effects

Stop taking this medicine and get emergency medical help if you have signs of an allergic reaction: fever, general ill feeling, trouble breathing, tiredness; joint or muscle pain, blisters or mouth sores, redness or swelling in your eyes; blistering or peeling skin; swelling of your face, lips, tongue, or throat.

Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, fast or irregular heart rate, dizziness, feeling cold, or feeling very weak or tired.

Dolutegravir and lamivudine may cause serious side effects. Call your doctor at once if you have:

the first sign of any skin rash, no matter how mild; or

liver problems--nausea, vomiting, loss of appetite, upper stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Dolutegravir and lamivudine affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

signs of a new infection--fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;

trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or

swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common side effects of dolutegravir and lamivudine may include:

headache;

tiredness;

nausea, diarrhea; or

sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Dolutegravir and lamivudine

You should not use this medicine if you are allergic to dolutegravir or lamivudine, or if you are also taking dofetilide (Tikosyn).

Tell your doctor if you have ever had:

kidney problems; or

liver disease, especially hepatitis B or C.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you are overweight, or if you are a woman. Ask your doctor about your risk.

You may need to have a negative pregnancy test before starting this treatment.

Dolutegravir and lamivudine may harm an unborn baby if you take the medicine at the time of conception or during the first 12 weeks of pregnancy. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breastfeed. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

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How to use Dolutegravir and lamivudine

Usual Adult Dose for HIV Infection:

1 tablet orally once a dayUses: As a complete regimen, for the treatment of HIV-1 infection in patients with no antiretroviral treatment history or to replace a stable antiretroviral regimen in patients who are virologically-suppressed (HIV-1 RNA less than 50 copies/mL) with no history of treatment failure and no known substitutions associated with resistance to the individual components

Warnings

You should not use dolutegravir and lamivudine if you are also taking dofetilide (Tikosyn).

Taking dolutegravir and lamivudine during the first trimester of pregnancy may cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine.

If you've ever had hepatitis B, it may become active and resistant to medication while you are taking dolutegravir and lamivudine. Hepatitis B may also get worse after you stop using this medicine. You may need frequent liver function tests for several months.

What other drugs will affect Dolutegravir and lamivudine

Some medicines can make dolutegravir and lamivudine much less effective when taken at the same time. If you take any of the following medicines, take your dolutegravir and lamivudine dose 2 hours before or 6 hours after you take the other medicine.

antacids or laxatives that contain calcium, magnesium, or aluminum (such as Amphojel, Di-Gel Maalox, Milk of Magnesia, Mylanta, Pepcid Complete, Rolaids, Rulox, Tums, and others), or the ulcer medicine sucralfate (Carafate);

buffered medicine; or

vitamin or mineral supplements that contain calcium or iron (but if you take dolutegravir with food, you can take these supplements at the same time).

Many drugs can affect dolutegravir and lamivudine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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