Doptelet

Generic name: Avatrombopag
Drug class: Platelet-stimulating agents

Usage of Doptelet

Doptelet is used to treat thrombocytopenia (a lack of platelets in the blood) in adults with chronic liver disease who are scheduled to undergo a medical procedure.

A low platelet count increases the risk of excessive bleeding during certain medical procedures. Avatrombopag increases the production of platelets by your body to help prevent too much bleeding.

Doptelet is also used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough.

Doptelet is also used to treat chronic immune thrombocytopenia when other treatments have failed.

Doptelet is not a cure for thrombocytopenia and it will not make your platelet counts normal in adults with chronic liver disease or chronic immune thrombocytopenia.

Doptelet side effects

Get emergency medical help if you have signs of an allergic reaction to Doptelet: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You could develop a blood clot while using avatrombopag. Call your doctor or get emergency medical help if you have:

chest pain, shortness of breath;

fast heartbeats;

pain, swelling, or redness in one or both legs;

stomach pain or tenderness;

sudden fever or chills, yellowing of your skin or eyes; or

bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common Doptelet side effects may include:

fever;

easy bruising or bleeding (nosebleeds, bleeding gums), purple or red spots on your skin;

feeling tired;

headache, joint pain;

cold symptoms such as runny or stuffy nose, sneezing, sore throat;

nausea, stomach pain; or

swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Doptelet

You should not use Doptelet if you are allergic to avatrombopag.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

a blood clot; or

a bleeding or blood clotting disorder other than thrombocytopenia.

Your doctor will measure your platelet levels with a blood test before you start taking this medicine.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

You should not breast-feed while using Doptelet, and for at least 2 weeks after your last dose.

Relate drugs

How to use Doptelet

Usual Adult Dose for Thrombocytopenia:

Chronic Liver Disease:

Platelet count less than 40 x 109/L: 60 mg orally once a day starting 10 to 13 days prior to the scheduled procedure

Platelet count 40 to less than 50 x 109/L: 40 mg orally once a day starting 10 to 13 days prior to the scheduled procedure.

Duration of therapy: 5 days

Comments: Patients should undergo their procedure 5 to 8 days after the last dose of this drug.

Use: Treatment of thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a procedure.

Chronic Immune Thrombocytopenia: 20 mg orally once a day. Adjust the dose or frequency of dosing to maintain platelet count greater than or equal to 50 x109/L. Do not exceed 40 mg per day.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Doptelet

Other drugs may interact with avatrombopag, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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