Doravirine

Generic name: Doravirine
Brand names: Pifeltro
Dosage form: oral tablet (100 mg)
Drug class: NNRTIs

Usage of Doravirine

Doravirine is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Doravirine is used together with other medicines to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Doravirine is not a cure for HIV or AIDS.

Doravirine may also be used for purposes not listed in this medication guide.

Doravirine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Doravirine affects your immune system, which may cause certain side effects (even weeks or months after you've taken doravirine). Tell your doctor if you have:

  • signs of a new infection--fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;
  • trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

    • Common side effects of doravirine may include:

  • nausea, diarrhea, stomach pain;
  • headache, dizziness;
  • tiredness; or
  • strange dreams.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Doravirine

    You should not use doravirine if you are allergic to it.

    Many drugs can interact and cause dangerous effects. Some drugs should not be used together with doravirine. Your doctor may change your treatment plan if you have used any of the following medicines in the past 4 weeks:

  • enzalutamide;
  • mitotane;
  • rifampin;
  • rifapentine;
  • St. John's wort; or
  • seizure medicine--Carbamazepine, phenobarbital, phenytoin, or oxcarbazepine.

    • Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

    Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

    doravirine is not approved for use by anyone younger than 18 years old.

    Relate drugs

    How to use Doravirine

    Usual Adult Dose for HIV Infection:

    100 mg orally once a dayUse: In combination with other antiretroviral agents, for the treatment of HIV-1 infection in patients: with no prior antiretroviral treatment history, OR to replace the current antiretroviral regimen in patients virologically-suppressed (HIV-1 RNA less than 50 copies/mL) on a stable antiretroviral regimen with no history of treatment failure and no known substitutions associated with resistance to this drug

    Usual Pediatric Dose for HIV Infection:

    At least 35 kg: 100 mg orally once a dayUse: In combination with other antiretroviral agents, for the treatment of HIV-1 infection in patients: with no prior antiretroviral treatment history, OR to replace the current antiretroviral regimen in patients virologically-suppressed (HIV-1 RNA less than 50 copies/mL) on a stable antiretroviral regimen with no history of treatment failure and no known substitutions associated with resistance to this drug

    Warnings

    Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

    What other drugs will affect Doravirine

    Tell your doctor about all your other medicines, especially:

  • rifabutin (or if you have taken it in the past 4 weeks).

    • This list is not complete. Other drugs may affect doravirine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

    Disclaimer

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