Doravirine, lamivudine, and tenofovir

Generic name: Doravirine, Lamivudine, And Tenofovir
Brand names: Delstrigo
Dosage form: oral tablet (100 mg-300 mg-300 mg)
Drug class: Antiviral combinations

Usage of Doravirine, lamivudine, and tenofovir

Doravirine, lamivudine, and tenofovir are antiviral medicines that prevent human immunodeficiency virus (HIV) from multiplying in your body.

Doravirine, lamivudine, and tenofovir is a combination medicine used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). doravirine, lamivudine, and tenofovir is not a cure for HIV or AIDS.

Doravirine, lamivudine, and tenofovir may also be used for purposes not listed in this medication guide.

Doravirine, lamivudine, and tenofovir side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Doravirine, lamivudine, and tenofovir may cause serious side effects. Call your doctor at once if you have:

urinating more or less than usual;

increased thirst;

new or worsening bone pain;

muscle pain or weakness; or

pain in your arms, legs, hands, or feet.

Doravirine, lamivudine, and tenofovir affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:

signs of a new infection--fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;

trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or

swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common side effects of doravirine, lamivudine, and tenofovir may include:

nausea;

dizziness; or

strange dreams.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Doravirine, lamivudine, and tenofovir

You should not use this medicine if you are allergic to doravirine, lamivudine, or tenofovir.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with doravirine, lamivudine, and tenofovir. Your doctor may change your treatment plan if you have used any of the following medicines in the past 4 weeks:

enzalutamide;

mitotane;

rifampin;

rifapentine;

St. John's wort; or

seizure medicine--Carbamazepine, phenobarbital, phenytoin, or oxcarbazepine.

Tell your doctor if you have ever had:

hepatitis B;

kidney disease; or

bone problems (including a broken bone, or osteoporosis).

You may be more likely to have a broken bone while using doravirine, lamivudine, and tenofovir. Talk with your doctor about ways to keep your bones healthy.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

This medicine is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Doravirine, lamivudine, and tenofovir

Usual Adult Dose for HIV Infection:

1 tablet orally once a dayUse: As a complete regimen, for the treatment of HIV-1 infection in patients with no prior antiretroviral treatment history or to replace the current antiretroviral regimen in patients virologically-suppressed (HIV-1 RNA less than 50 copies/mL) on a stable antiretroviral regimen with no history of treatment failure and no known substitutions associated with resistance to the components of this drug

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

If you've ever had hepatitis B, it may become active or get worse after you stop using doravirine, lamivudine, and tenofovir. You may need frequent liver function tests for several months.

What other drugs will affect Doravirine, lamivudine, and tenofovir

Doravirine, lamivudine, and tenofovir can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve).

Tell your doctor about all your other medicines, especially:

rifabutin (or if you have taken it in the past 4 weeks).

This list is not complete. Other drugs may affect doravirine, lamivudine, and tenofovir, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.