Doxylamine and pyridoxine

Generic name: Doxylamine And Pyridoxine
Drug class: Miscellaneous antiemetics

Usage of Doxylamine and pyridoxine

Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body.

Pyridoxine is a form of vitamin B (B6).

Doxylamine and pyridoxine is a combination medicine used to treat nausea and vomiting during pregnancy, sometimes called morning sickness.

Doxylamine and pyridoxine may also be used for purposes not listed in this medication guide.

Doxylamine and pyridoxine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects of doxylamine and pyridoxine may include:

drowsiness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Doxylamine and pyridoxine

Do not use doxylamine and pyridoxine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use this medicine if you are allergic to doxylamine or pyridoxine, or to other antihistamines such as Benadryl or Dramamine.

Tell your doctor if you have ever had:

asthma or other breathing disorder;

glaucoma, increased pressure inside your eye;

blockage in your digestive tract (stomach or intestines);

a stomach ulcer; or

bladder obstruction or other urination problems.

You should not breast-feed while using doxylamine and pyridoxine.

Doxylamine and pyridoxine is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Doxylamine and pyridoxine

Usual Adult Dose for Nausea/Vomiting:

Doxylamine 10 mg-pyridoxine 10 mg delayed-release tablets:-Initial dose: 2 tablets orally once a day at bedtime-Maintenance dose: 2 tablets orally once a day to 4 tablets orally 3 times a day-Maximum dose: 4 tablets/dayDoxylamine 20 mg-pyridoxine 20 mg extended-release tablets:-Initial dose: 1 tablet orally once a day at bedtime-Maximum dose: 2 tablets/dayComments:-Treatment should be taken as prescribed, and should not be taken on an as-needed basis.-Patients should be routinely reassessed for the continued need for treatment.Use: Treatment of nausea and vomiting of pregnancy in patients who do not respond to conservative management

Warnings

Do not use doxylamine and pyridoxine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

What other drugs will affect Doxylamine and pyridoxine

Using doxylamine and pyridoxine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may affect doxylamine and pyridoxine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

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