Duavee
Generic name: Bazedoxifene And Conjugated Estrogens
Drug class:
Sex hormone combinations
Usage of Duavee
Duavee contains a combination of Bazedoxifene and conjugated estrogens. Bazedoxifene blocks estrogen from reaching certain cells in the uterine lining, to protect against overgrowth of uterine tissue.
Estrogen is a female sex hormone produced by the ovaries. Conjugated estrogens are a mixture of estrogen hormones.
Duavee is used short-term in women after menopause to treat moderate to severe hot flashes, and to prevent osteoporosis.
Duavee is used in women who have NOT had a hysterectomy (uterus removed).
Duavee side effects
Get emergency medical help if you have signs of an allergic reaction to Duavee: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
Common Duavee side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Duavee
You should not use Duavee if you are allergic to bazedoxifene or conjugated estrogens, or if you have:
Do not use other estrogen products while you are taking Duavee.
Using this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.
Duavee should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.
Women who are 75 or older should not take Duavee.
Tell your doctor if you have ever had:
Use of Duavee may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.
This medicine is for use only in women who can no longer get pregnant. Bazedoxifene and conjugated estrogens can harm an unborn baby. Do not use if you are pregnant. Use effective birth control if you are not past menopause. Tell your doctor if you think you may be pregnant.
You should not breast-feed while using this medicine.
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How to use Duavee
Usual Adult Dose for Osteoporosis:
Initial dose: Bazedoxifene-conjugated estrogens 20 mg-0.45 mg tablet orally daily Duration of therapy: Bazedoxifene-conjugated estrogens should be for the shortest duration consistent with treatment goals and risks for the patient. Approved indication: Treatment of Moderate to Severe Vasomotor Symptoms Associated with Menopause and Prevention of Postmenopausal Osteoporosis.
Usual Adult Dose for Postmenopausal Symptoms:
Initial dose: Bazedoxifene-conjugated estrogens 20 mg-0.45 mg tablet orally daily Duration of therapy: Bazedoxifene-conjugated estrogens should be for the shortest duration consistent with treatment goals and risks for the patient. Approved indication: Treatment of Moderate to Severe Vasomotor Symptoms Associated with Menopause and Prevention of Postmenopausal Osteoporosis.
Warnings
You should not use Duavee if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.
Using Duavee can increase your risk of blood clots, stroke, or heart attack, or cancer of the breast, uterus, or ovaries. Estrogens should not be used to prevent heart disease, stroke, or dementia.
Estrogens may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.
Duavee is for short-term use at the lowest dose needed to treat your condition.
Do not take any other estrogens while you are taking this medicine.
What other drugs will affect Duavee
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can interact with bazedoxifene and conjugated estrogens. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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