Eculizumab
Generic name: Eculizumab
Brand names: Soliris
Dosage form: intravenous solution (10 mg/mL)
Drug class:
Selective immunosuppressants
Usage of Eculizumab
Eculizumab is used in adults to treat myasthenia gravis or neuromyelitis optica spectrum disorder.
Eculizumab is also used to prevent the breakdown of red blood cells in adults with paroxysmal nocturnal hemoglobinuria.
Eculizumab is used in adults and children weighing at least 11 pounds (5 kilograms) to treat a blood disease called atypical hemolytic uremic syndrome.
Eculizumab is available only under a special program. You must be registered in the program and understand the risks and benefits of eculizumab.
Eculizumab may also be used for purposes not listed in this medication guide.
Eculizumab side effects
Get emergency medical help if you have signs of an allergic Reaction: hives; chest pain, difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat. These symptoms may occur during the injection.
Seek emergency medical attention if you have symptoms of meningitis:
During or after your treatment with eculizumab call your doctor at once if you have:
Common side effects of eculizumab may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Eculizumab
You should not use eculizumab if:
Tell your doctor if you have a fever or any type of infection.
Your doctor may recommend certain vaccines. You must be vaccinated against meningococcal infection at least 2 weeks before you start treatment with eculizumab. If you were vaccinated in the past, you may need a booster dose.
Follow your doctor's instructions about using eculizumab if you are pregnant. It is very important to control your blood disorder during pregnancy to avoid unwanted effects in you or the baby.
Ask a doctor if it is safe to breastfeed while using this medicine.
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How to use Eculizumab
Your doctor will perform tests to make sure eculizumab is the right treatment for you.
Eculizumab is injected into a vein by a healthcare provider. The infusion can take at least 35 minutes to complete in adults, or up to 4 hours in children.
Eculizumab is not given every day. Follow your doctor's dosing instructions very carefully. The dosing schedule may be different for a child or teenager than for an adult.
Doses are based on weight in children and teenagers. Your child's dose may change if the child gains or loses weight.
You should be watched closely for at least 1 hour after each infusion, to make sure you do not have a reaction.
You may get infections more easily, even serious or fatal infections. You will need frequent medical tests.
You will receive a card listing the symptoms of meningococcal infection. Read this information and learn what symptoms to watch for. Keep the card with you at all times while using eculizumab and for at least 3 months after your last dose.
Do not stop receiving eculizumab without first talking to your doctor. Interrupting your treatment could cause sudden and serious effects on your red blood cells.
Eculizumab can effect your body for up to 3 months. You may need medical tests for 8 to 12 weeks if you stop using this medicine. Make sure any doctor who treats you knows that you've used eculizumab.
Warnings
You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have a headache and fever with nausea or vomiting, skin rash, body aches, flu symptoms, confusion, sensitivity to light, or stiffness in your neck or back.
Read the Patient Safety Card about meningococcal infection and learn what symptoms to watch for. Keep the card with you at all times while using eculizumab and for at least 3 months after your last dose.
You must be vaccinated against meningococcal infection at least 2 weeks before treatment with eculizumab.
What other drugs will affect Eculizumab
Other drugs may affect eculizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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