Edurant
Generic name: Rilpivirine
Drug class:
NNRTIs
Usage of Edurant
Edurant is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.
Edurant is used in combination with other antiviral medicines to treat HIV. Edurant is for use in adults and children at least 12 years old who weigh at least 77 pounds (35 kilograms) who have never before taken an HIV medicine and who have an amount of HIV-1 in their blood (this is called 'viral load') that is no more than 100,000 copies/mL. Edurant is not a cure for HIV or AIDS..
Edurant is sometimes used with a medicine called Cabotegravir as a daily "lead-in dose" to help determine that you can safely use a combination form of these medicines given as a monthly injection. Edurant and cabotegravir may also be given short-term in place of the monthly injectable combination for up to 2 months. When used with cabotegravir for these purposes, Edurant is only for adults with HIV who have already used other antiviral medicines that have controlled their viral load.
Edurant side effects
Get emergency medical help if you have signs of an allergic Reaction to Edurant (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Call your doctor at once if you have:
Edurant affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:
Common Edurant side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Edurant
You should not use Edurant if you are allergic to rilpivirine.
Some medicines can cause unwanted or dangerous effects when used with Edurant. Your doctor may change your treatment plan if you also use:
Tell your doctor if you have ever had:
Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.
Women with HIV or AIDS should not breastfeed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
Edurant is not approved for use by anyone younger than 12 years old or weighing less than 77 pounds (35 kilograms).
Relate drugs
- Doravirine
- Edurant
- Efavirenz
- Etravirine
- Intelence
- Nevirapine
- Pifeltro
- Rescriptor
- Rilpivirine
- Sustiva
- Viramune
- Viramune O/S
- Viramune XR
How to use Edurant
Usual Adult Dose for HIV Infection:
25 mg orally once a day Comments (for Treatment of HIV-1 in Combination with Cabotegravir): -The manufacturer product information for cabotegravir-rilpivirine IM should be consulted before starting this drug to ensure therapy with cabotegravir-rilpivirine IM is appropriate. -This drug should be taken with cabotegravir tablets (30 mg orally once a day) at about the SAMe time each day with a meal; the manufacturer product information for cabotegravir tablets should be consulted. -To assess tolerability of this drug, oral lead-in should be used for about 1 month (at least 28 days) before the initiation of cabotegravir-rilpivirine IM. -The final oral dose should be administered on the same day injections with cabotegravir-rilpivirine are started. -If a patient plans to miss a scheduled cabotegravir-rilpivirine injection visit by more than 7 days, daily oral therapy may be used to replace up to 2 consecutive monthly injection visits; the first dose of oral therapy should be administered about 1 month after the last injection dose of cabotegravir-rilpivirine IM and continued until the day injection dosing is restarted. The manufacturer product information for cabotegravir-rilpivirine IM should be consulted to resume monthly injection dosing. Uses: -In combination with other antiretroviral agents, for the treatment of HIV-1 infection in antiretroviral therapy-naive patients with plasma HIV-1 RNA up to 100,000 copies/mL at the start of therapy -In combination with cabotegravir tablets, for short-term treatment of HIV-1 infection in patients who are virologically suppressed (HIV-1 RNA less than 50 copies/mL) on a stable antiretroviral regimen with no history of treatment failure and with no known/suspected resistance to either cabotegravir or rilpivirine, for use as: ---Oral lead-in to assess tolerability of this drug before starting rilpivirine IM (a component of cabotegravir-rilpivirine IM) ---Oral therapy for patients who will miss planned injection dosing with cabotegravir-rilpivirine IM
Usual Pediatric Dose for HIV Infection:
12 years or older, weighing at least 35 kg: 25 mg orally once a day Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection in antiretroviral therapy-naive patients with plasma HIV-1 RNA up to 100,000 copies/mL at the start of therapy
Warnings
Before you take Edurant, tell your doctor if you have liver disease (including hepatitis B or C), kidney disease, a history of depression or mental illness, or if you have ever taken any HIV medication in the past.
Some medicines can interact with rilpivirine and should not be used at the same time. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Do not take Edurant as your only HIV medication. Rilpivirine must be used in combination with other HIV medicines that your doctor has prescribed.
Call your doctor at once if you have mood changes, anxiety, severe depression, feeling hopeless, or thoughts about suicide or hurting yourself.
Taking this medication will not prevent you from passing HIV to other people.
What other drugs will affect Edurant
Some medicines can make Edurant much less effective when taken at the same time. If you take any of the following medicines, take them separately from your dose of Edurant:
Edurant can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Many drugs can interact with rilpivirine, and some drugs should not be used at the same time. Tell your doctor about all your current medicines and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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