E.E.S. Granules

Generic name: Erythromycin
Drug class: Macrolides

Usage of E.E.S. Granules

Erythromycin is used to prevent and treat infections in many different parts of the body, including respiratory tract infections, skin infections, diphtheria, intestinal amebiasis, acute pelvic inflammatory disease, Legionnaire's disease, pertussis, and syphilis. This medicine is also used to prevent recurrent attacks of rheumatic fever in patients who have had an allergic Reaction to penicillin or sulfa drugs.

Erythromycin belongs to the class of medicines known as macrolide antibiotics. It works by killing bacteria or preventing their growth.

This medicine is available only with your doctor's prescription.

E.E.S. Granules side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Blistering, peeling, or loosening of the skin

chills

cough

diarrhea

difficulty with swallowing

dizziness

fast heartbeat

hives or welts, skin rash

joint or muscle pain

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red, irritated eyes

red skin lesions, often with a purple center

redness of the skin

sore throat

sores, ulcers, or white spots in the mouth or on the lips

tightness in the chest

unusual tiredness or weakness

Incidence not known

Bloating

bloody or cloudy urine

chest pain or discomfort

dark urine

diarrhea, watery and severe, which may also be bloody

fainting

fever

general tiredness and weakness

greatly decreased frequency of urination or amount of urine

hearing loss

increased thirst

irregular heartbeat recurrent

irregular or slow heart rate

light-colored stools

nausea

pain

stomach cramp or tenderness

swelling of the feet or lower legs

unusual weight loss

upper right abdominal or stomach pain

vomiting

yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Diarrhea (mild)

loss of appetite

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking E.E.S. Granules

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of erythromycin in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of erythromycin in the elderly. However, elderly patients are more likely to have erythromycin-induced hearing loss, heart rhythm problems, and bleeding problems.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Astemizole

Bepridil

Cisapride

Colchicine

Dihydroergotamine

Dronedarone

Eliglustat

Ergotamine

Flibanserin

Fluconazole

Grepafloxacin

Levoketoconazole

Levomethadyl

Lomitapide

Lovastatin

Mesoridazine

Pimozide

Piperaquine

Posaconazole

Saquinavir

Simvastatin

Sparfloxacin

Terfenadine

Thioridazine

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir

Acalabrutinib

Acecainide

Adagrasib

Afatinib

Ajmaline

Alfentanil

Alprazolam

Amiodarone

Amisulpride

Amitriptyline

Amlodipine

Amoxapine

Anagrelide

Apixaban

Apomorphine

Aprepitant

Aprindine

Aripiprazole

Aripiprazole Lauroxil

Arsenic Trioxide

Ascorbic Acid

Asenapine

Atazanavir

Atorvastatin

Avapritinib

Azimilide

Azithromycin

Bedaquiline

Benzhydrocodone

Berotralstat

Betrixaban

Bosutinib

Bretylium

Brexpiprazole

Brigatinib

Buprenorphine

Buserelin

Carbamazepine

Ceritinib

Cerivastatin

Chloral Hydrate

Chloroquine

Chlorpromazine

Cholera Vaccine, Live

Cilostazol

CiprOfloxacin

Citalopram

Clarithromycin

Clindamycin

Clofazimine

Clomipramine

Clothiapine

Clozapine

Cobicistat

Cobimetinib

Codeine

Conivaptan

Crizotinib

Cyclobenzaprine

Dabigatran Etexilate

Dabrafenib

Daridorexant

Darunavir

Dasatinib

Deflazacort

Degarelix

Delamanid

Desipramine

Deslorelin

Deutetrabenazine

Dexmedetomidine

Dibenzepin

Digoxin

Dihydrocodeine

Diltiazem

Disopyramide

Dofetilide

Dolasetron

Domperidone

Donepezil

Doxepin

Doxorubicin

Doxorubicin Hydrochloride Liposome

Droperidol

Edoxaban

Efavirenz

Elacestrant

Elexacaftor

Encainide

Encorafenib

Enflurane

Entrectinib

Eplerenone

Escitalopram

Etrasimod

Everolimus

Fedratinib

Felodipine

Fentanyl

Fexinidazole

Finerenone

Fingolimod

Flecainide

Fluoxetine

Formoterol

Fosaprepitant

Foscarnet

Fosnetupitant

Fostemsavir

Gatifloxacin

Gemifloxacin

Gepirone

Glasdegib

Gonadorelin

Goserelin

Granisetron

Halofantrine

Haloperidol

Halothane

Histrelin

Hydrocodone

HydroQuinidine

Hydroxychloroquine

Hydroxyzine

Ibrutinib

Ibutilide

Ifosfamide

Iloperidone

Imipramine

Infigratinib

Inotuzumab Ozogamicin

Isoflurane

Isradipine

Itraconazole

Ivabradine

Ivacaftor

Ivosidenib

Ketoconazole

Lapatinib

Larotrectinib

Lefamulin

Lemborexant

Leniolisib

Lenvatinib

Leuprolide

Levofloxacin

Lidoflazine

Lofexidine

Lopinavir

Lorcainide

Lumacaftor

Lumateperone

Lumefantrine

Lurasidone

Lurbinectedin

Macimorelin

Mavacamten

Mefloquine

Meperidine

Methadone

Methotrexate

Metronidazole

Mifepristone

Mirtazapine

Mitapivat

Mobocertinib

Morphine

Morphine Sulfate Liposome

Moxifloxacin

Nafarelin

Naloxegol

Neratinib

Netupitant

Nifedipine

Nilotinib

Nirmatrelvir

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Olanzapine

Olaparib

Omaveloxolone

Ondansetron

Osilodrostat

Osimertinib

Oxaliplatin

Oxycodone

Ozanimod

Pacritinib

Paliperidone

Palovarotene

Panobinostat

Paroxetine

Pasireotide

Pazopanib

Pemigatinib

Pentamidine

Pentazocine

Pexidartinib

Pimavanserin

Pirmenol

Pitavastatin

Pitolisant

Pixantrone

Ponesimod

Prajmaline

Pralsetinib

Probucol

Procainamide

Prochlorperazine

Promethazine

Propafenone

Protriptyline

Quetiapine

Quinidine

Quinine

Quizartinib

Ranolazine

Relugolix

Ribociclib

Rimegepant

Risperidone

Ritonavir

Rivaroxaban

Selpercatinib

Selumetinib

Sematilide

Sertindole

Sertraline

Sevoflurane

Simeprevir

Siponimod

Sirolimus Protein-Bound

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sonidegib

Sorafenib

Sotalol

Sparsentan

Spiramycin

Sufentanil

Sulfamethoxazole

Sulpiride

Sultopride

Sunitinib

Tacrolimus

Tadalafil

Tazemetostat

Tedisamil

Telaprevir

Telavancin

Telithromycin

Tenofovir Alafenamide

Tetrabenazine

Tezacaftor

Theophylline

Tolvaptan

Toremifene

Tramadol

Trazodone

Triclabendazole

Trifluoperazine

Trimethoprim

Trimipramine

Triptorelin

Troleandomycin

Ubrogepant

Vandetanib

Vardenafil

Vemurafenib

Venetoclax

Venlafaxine

Verapamil

Vilanterol

Vinblastine

Vincristine

Vincristine Sulfate Liposome

Vinflunine

Voclosporin

Voriconazole

Warfarin

Zanubrutinib

Zolmitriptan

Zolpidem

Zotepine

Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Anisindione

Avanafil

Bexarotene

Budesonide

Buspirone

Cyclosporine

Diazepam

Dicumarol

Methylprednisolone

Midazolam

Phenprocoumon

Roflumilast

Sildenafil

Sirolimus

Suvorexant

Tolterodine

Triazolam

Trimetrexate

Valproic Acid

Zafirlukast

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Relate drugs

How to use E.E.S. Granules

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Take this medicine with or without food. PCE® tablets may be taken without meals or at least 30 minutes to 2 hours before meals.

Measure the mixed oral liquid with a marked measuring spoon, oral syringe, or medicine cup.

Keep using the medicine for the full time of treatment, even if you or your child begin to feel better after the first few doses. Your infection may not go away if you stop using the medicine too soon.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (granules for suspension, suspension, and tablets):

For treatment of bacterial infections:

Adults—400 milligrams (mg) every 6 hours or 800 mg every 12 hours. Depending on the severity of your infection, your doctor may increase your dose as needed up to 4000 mg per day.

Children—Dose is based on body weight and must be determined by your doctor. The dose is usually 30 to 50 milligrams (mg) per kilogram (kg) of body weight per day, divided in equal doses and taken every 6 hours. Depending on the severity of your infection, your doctor may increase your dose as needed.

For oral dosage form (PCE® tablets):

For prevention of recurring attacks of rheumatic fever:

Adults—250 milligrams (mg) 2 times a day.

Children—Use and dose must be determined by your doctor.

For treatment of bacterial infections:

Adults—333 milligrams (mg) every 8 hours or 500 mg every 12 hours. Depending on the severity of your infection, your doctor may increase your dose as needed up to 4000 mg per day.

Children—Dose is based on body weight and must be determined by your doctor. The dose is usually 30 to 50 milligrams (mg) per kilogram (kg) of body weight per day, divided in equal doses. Depending on the severity of your infection, your doctor may increase your dose as needed.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the mixed E.E.S.® oral liquid in the refrigerator. Throw away any unused medicine within 10 days.

Store the mixed Ery-Ped® oral liquid at room temperature. Throw away any unused medicine within 35 days.

Warnings

It is very important that your doctor check you or your child's progress at regular visits to make sure this medicine is working properly and to check for unwanted effects. If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Do not use this medicine if you or your child are also using astemizole (Hismanal®), cisapride (Propulsid®), ergotamine (Cafergot®, Ergomar®), dihydroergotamine (Migranal®), pimozide (Orap®), terfenadine (Seldane®), or statin medicine (eg, lovastatin, simvastatin, Mevacor®, Zocor®). Using these medicines together may increase risk for more serious side effects.

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine can cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you or your child have worsening symptoms of heart rhythm problems, such as fast, pounding, or uneven heartbeat.

Make sure your doctor knows if you are pregnant or may be pregnant before using this medicine.

Erythromycin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Before you have any medical tests, tell the medical doctor in charge that you or your child are using this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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