Efavirenz

Generic name: Efavirenz
Brand names: Sustiva
Drug class: NNRTIs

Usage of Efavirenz

Efavirenz is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body.

Efavirenz is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Efavirenz is for adults and children who are at least 3 months old and weigh at least 8 pounds. Efavirenz is not a cure for HIV or AIDS.

Efavirenz may also be used for purposes not listed in this medication guide.

Efavirenz side effects

Get emergency medical help if you have signs of an allergic Reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Efavirenz may cause serious side effects. Call your doctor at once if you have:

a seizure;

hallucinations, trouble concentrating, trouble speaking or moving (these symptoms may occur months or years after you start taking efavirenz);

nervous system problems--dizziness, drowsiness, confusion, trouble concentrating, strange dreams, insomnia, or problems with speech, balance, or muscle movement;

serious psyChiatric symptoms--anxiety, paranoia, unusual behavior, feeling sad or hopeless, hallucinations, suicidal thoughts; or

liver problems--nausea, stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

Psychiatric symptoms or nervous system problems may happen even months or years after you have been taking efavirenz.

Efavirenz affects your immune system, which may cause certain side effects (even weeks or months after you've taken efavirenz). Tell your doctor if you have:

signs of a new infection--fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;

trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or

swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common side effects of efavirenz may include:

nausea, vomiting;

dizziness, drowsiness, trouble concentrating;

rash;

headache, tired feeling;

sleep problems (insomnia), strange dreams; or

changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Efavirenz

You should not use efavirenz if you are allergic to it, or if you also take Elbasvir and grazoprevir (Zepatier) to treat hepatitis C.

Do not take with Atripla (combination Emtricitabine, and Tenofovir" href="/drugs/efavirenz-emtricitabine-and-tenofovir-4757/">Efavirenz, emtricitabine, and tenofovir), unless your doctor tells you to.

Tell your doctor if you have ever had:

liver disease (including hepatitis B or C);

long QT syndrome;

a seizure;

mental illness or psychosis;

heart disease; or

if you drink large amounts of alcohol or have a history of injection drug use.

Do not use efavirenz if you are pregnant. It could harm the unborn baby or cause birth defects. Use 2 forms of birth control, including a barrier form (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy while you are using efavirenz and for at least 12 weeks after your last dose. Tell your doctor if you become pregnant during treatment.

Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy while you are taking efavirenz.

HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

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How to use Efavirenz

Usual Adult Dose for HIV Infection:

600 mg orally once a dayComments:-This drug should be used with a protease inhibitor and/or NRTIs.Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Usual Adult Dose for Nonoccupational Exposure:

US CDC recommendations: 600 mg orally once a dayDuration of therapy: 28 daysComments:-This drug should be used with (lamivudine or emtricitabine) plus (zidovudine or tenofovir); recommended as the preferred NNRTI-based regimen for nonoccupational postexposure prophylaxis of HIV infection.-Prophylaxis should be started as soon as possible, within 72 hours of exposure.-Not approved by US FDA.

Usual Adult Dose for Occupational Exposure:

US Public Health Service working group recommendations: 600 mg orally once a dayDuration of therapy: 28 days, if toleratedComments:-An alternative antiretroviral agent for use as HIV postexposure prophylaxis only with expert consultation-Prophylaxis should be started as soon as possible, preferably within hours after exposure.-The optimal duration of prophylaxis is unknown and may differ based on institution protocol.-The most current therapeutic guidelines should be consulted for more information.-Not approved by US FDA.

Usual Pediatric Dose for HIV Infection:

3 months or older:3.5 to less than 5 kg: 100 mg orally once a day5 to less than 7.5 kg: 150 mg orally once a day7.5 to less than 15 kg: 200 mg orally once a day15 to less than 20 kg: 250 mg orally once a day20 to less than 25 kg: 300 mg orally once a day25 to less than 32.5 kg: 350 mg orally once a day32.5 to less than 40 kg: 400 mg orally once a day40 kg or more: 600 mg orally once a dayUse: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Warnings

You should not use efavirenz if you also take elbasvir and grazoprevir (Zepatier) to treat hepatitis C.

What other drugs will affect Efavirenz

Sometimes it is not safe to use certain medications at the SAMe time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Efavirenz can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Other drugs may affect efavirenz, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

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