Eflapegrastim

Generic name: Eflapegrastim
Brand names: Rolvedon
Dosage form: subcutaneous solution (xnst 13.2 mg/0.6 mL)
Drug class: Colony stimulating factors

Usage of Eflapegrastim

Eflapegrastim is used in adults to treat Neutropenia, a lack of certain white blood cells caused by cancer, chemotherapy, or by other conditions.

Eflapegrastim is used in adults to treat neutropenia, a lack of certain white blood cells caused by cancer, bone marrow transplant, receiving chemotherapy, or by other conditions.

Eflapegrastim may also be used for purposes not listed in this medication guide.

Eflapegrastim side effects

Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Eflapegrastim can cause your spleen to become enlarged and it could rupture (tear). Call your doctor right away if you have sudden or severe pain in your left upper stomach spreading up to your shoulder.

Capillary leak syndrome is a rare but serious side effect. Call your doctor right away if you have signs of this condition: stuffy or runny nose followed by tiredness, thirst, decreased urination, trouble breathing, and sudden swelling or weight gain.

Eflapegrastim may cause serious side effects. Call your doctor at once if you have:

  • shortness of breath or rapid breathing;
  • pain or trouble breathing;
  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • abdominal pain, tiredness, back pain;
  • signs of infection-- fever, chills, sore throat, body aches, unusual tiredness, loss of appetite; or
  • kidney problems--little or no urinating, blood in your urine, swelling in your face or ankles.

    • Common side effects of eflapegrastim may include:

  • nausea, diarrhea;
  • bone, muscle, or joint pain;
  • back pain;
  • headache;
  • tiredness;
  • rash;
  • fever; or
  • pale skin, feeling light-headed or short of breath, cold hands and feet.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Eflapegrastim

    You should not use eflapegrastim if you are allergic to eflapegrastim, Filgrastim, or pegeflapegrastim.

    Tell your doctor if you have ever had:

  • sickle cell disorder; or
  • kidney disease.

    • Tell your doctor if you are pregnant or breastfeeding.

    Relate drugs

    How to use Eflapegrastim

    Usual Adult Dose for Neutropenia Associated with Chemotherapy:

    Usual dose: 13.2 mg suBCUTAneously once per chemotherapy cycle Comments:-Dose should be given at least 24 hours after cytotoxic chemotherapy.-This drug should not be administered within the period from 14 days before to 24 hours after administration of cytotoxic chemotherapy.-This drug is not indicated for the mobilization of peripheral blood progenitor cells for hematopoietic stem cell transplantation.Use: To decrease the incidence of infection, manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a significant incidence of neutropenia and fever.

    Warnings

    Eflapegrastim can cause your spleen to become enlarged and it could rupture (tear). Call your doctor right away if you have sudden or severe pain in your left upper stomach spreading up to your shoulder.

    What other drugs will affect Eflapegrastim

    Other drugs may affect eflapegrastim, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

    Disclaimer

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