Elagolix, estradiol, and norethindrone
Generic name: Elagolix, Estradiol, And Norethindrone
Brand names: Oriahnn
Dosage form: oral capsule (300 mg-1 mg-0.5 mg)
Drug class:
Sex hormone combinations
Usage of Elagolix, estradiol, and norethindrone
Elagolix, estradiol, and norethindrone (Oriahnn) is used to control heavy menstrual bleeding in adult women with uterine fibroids.
Oriahnn is not for use in women who have entered menopause.
Oriahnn may also be used for purposes not listed in this medication guide.
Elagolix, estradiol, and norethindrone side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Oriahnn may increase your risk of heart attack, stroke, or blood clot. Stop using this medicine and seek medical attention right away if you have:
Elagolix, estradiol, and norethindrone may cause serious side effects. Call your doctor at once if you have:
This medicine may cause hair loss that may be permanent.
Common side effects of elagolix, estradiol, and norethindrone may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Elagolix, estradiol, and norethindrone
You should not use elagolix, estradiol, and norethindrone if you are allergic to elagolix, estradiol, or norethindrone, or if you have:
Taking Oriahnn can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, or if you are overweight.
Smoking can greatly increase your risk of blood clots, stroke, or heart attack. You should not take this medicine if you smoke and are over 35 years old.
Oriahnn may also cause bone loss, which may be partially permanent. It is not known if this could increase your risk of bone fracture.
Oriahnn is not a birth control medication and will not prevent pregnancy. You may need to have a negative pregnancy test before starting this treatment.
Do not take this medicine if you are pregnant or trying to get pregnant. Oriahnn may increase your risk of miscarriage. Use effective birth control to prevent pregnancy while taking this medicine and for at least 1 week after your last dose.
To prevent pregnancy while using Oriahnn, use a non-hormonal form of birth control: condom, diaphragm, cervical cap, or contraceptive sponge. Avoid using birth control pills, injections, implants, skin patches, and vaginal rings.
Stop taking Oriahnn and call your doctor right away if you think you might be pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of Oriahnn on the baby.
Oriahnn may change your menstrual periods (decreased or no bleeding), which could make it harder to know if you are pregnant. Watch for other signs of pregnancy such as breast tenderness, weight gain, and nausea.
Tell your doctor if you have ever had:
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How to use Elagolix, estradiol, and norethindrone
Usual Adult Dose for Uterine Fibroids:
One capsule orally twice a day-Morning capsule contains elagolix 300 mg, estradiol 1 mg, and norethindrone acetate 0.5 mg-Evening capsule contains elagolix 300 mgDuration of therapy: 24 months Comments:-Rule out pregnancy prior to starting therapy or start therapy within 7 days from the onset of menses. -Take capsules twice a day at approximately the same time each day. -Duration of use should be limited to 24-months due to risk of bone loss. Use: For the management of heavy menstrual bleeding associated with uterine leiomyomas (fibroids) in premenopausal women.
Warnings
Do not use this medicine if you are pregnant.
You should not use this medicine if you have: uncontrolled high blood pressure, heart disease, circulation problems (especially with diabetes), undiagnosed vaginal bleeding, liver disease, severe migraine headaches, osteoporosis, if you smoke and are over 35, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.
Taking this medicine can increase your risk of blood clots, stroke, or heart attack. Your risk of these side effects is highest if you are older than 35 and you smoke, or if you have high cholesterol, diabetes, uncontrolled high blood pressure, or if you are overweight.
Stop taking this medicine and seek medical attention right away if you have chest pain spreading to your jaw or shoulder, a sudden severe headache, problems with vision or speech, or swelling or pain in your leg.
What other drugs will affect Elagolix, estradiol, and norethindrone
Tell your doctor about all your other medicines, especially:
Other drugs may affect elagolix, estradiol, and norethindrone, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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