Eluxadoline

Generic name: Eluxadoline
Brand names: Viberzi
Dosage form: oral tablet (100 mg; 75 mg)
Drug class: Peripheral opioid receptor mixed agonists / antagonists

Usage of Eluxadoline

Eluxadoline is used to treat irritable bowel syndrome when the main symptom is diarrhea.

Eluxadoline may also be used for purposes not listed in this medication guide.

Eluxadoline side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking eluxadoline and call your doctor at once if you have:

new or worsening stomach pain (may be severe);

nausea and vomiting;

severe constipation;

constipation lasting longer than 4 days; or

severe pain in your upper stomach spreading to your back.

Side effects may be more likely in older adults.

Common side effects of eluxadoline may include:

constipation;

nausea; or

stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Eluxadoline

You should not use eluxadoline if you are allergic to it, or if you have:

severe constipation or a blockage in your intestines;

a history of gallbladder obstruction, or if your gallbladder has been removed;

digestive problems caused by a muscle valve called the sphincter of Oddi (SFINK-ter of OD-dee);

severe liver disease;

a pancreas disorder; or

a habit of drinking more than 3 alcoholic beverages per day.

Tell your doctor if you have ever had:

liver disease; or

kidney disease (or if you are on dialysis).

Tell your doctor if you are pregnant or breastfeeding.

Eluxadoline is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Eluxadoline

Usual Adult Dose for Irritable Bowel Syndrome:

Usual dose: 100 mg orally twice a dayComments: -Dose should be reduced to 75 mg orally twice a day for patients unable to tolerate usual dose.-If severe constipation develops, this drug should be discontinued. Use: For the treatment of irritable bowel syndrome with diarrhea.

Warnings

You should not use eluxadoline if you have a pancreas disorder, severe liver disease, alcoholism, a blockage in your intestines, a gallbladder disorder, or if your gallbladder has been removed.

Eluxadoline may cause pancreatitis or constipation, which could be severe or lead to hospitalization. Call your doctor at once if you have severe or ongoing constipation, severe pain in your upper stomach spreading to your back (with or without nausea and vomiting).

What other drugs will affect Eluxadoline

Tell your doctor about all your other medicines, especially:

alosetron or other medications to treat irritable bowel syndrome;

opioid pain medicine;

medicine to treat depression, anxiety, mood disorders, or mental illness;

cold or allergy medicine (Benadryl and others);

medicine to treat Parkinson's disease;

medicine to treat stomach problems, motion sickness, or irritable bowel syndrome;

medicine to treat overactive bladder; or

bronchodilator asthma medication.

This list is not complete. Other drugs may affect eluxadoline, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.