Elyxyb

Generic name: Celecoxib
Dosage form: oral solution
Drug class: Cox-2 inhibitors

Usage of Elyxyb

Elyxyb is a ready-to-use oral solution containing Celecoxib that is used to treat migraine headaches in adults.

Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat conditions that cause pain and inflammation. Since 1998 celecoxib has been available in capsule form (Celebrex), but in 2020 the US Food and Drug Administration (FDA) approved Elyxyb oral solution.

Elyxyb oral solution is made using a self-micro emulsifying drug delivery system that enables celecoxib to be absorbed better and work faster. Elyxyb works within one hour to provide relief from a migraine attack.

Elyxyb is thought to work by inhibiting an enzyme called cyclooxygenase-2 (COX-2), which inhibits the production of a group of lipids called prostagladins. Prostagladins can cause inflammation and pain.

Elyxyb side effects

Elyxyb can cause serious side effects, including:

  • See "Important information" above
  • liver problems including liver failure
  • new or worse high blood pressure
  • heart failure
  • kidney problems including kidney failure
  • life-threatening allergic reactions
  • asthma attacks in people who have asthma
  • life-threatening skin reactions
  • medication overuse headaches. Some people who use too much Elyxyb may have worse headaches (medication overuse headache). If your headaches get worse, your healthcare provider may decide to stop your treatment with Elyxyb.
  • low red blood cells (anemia)
  • Other side effects of NSAIDs include: stomach pain, constipation, diarrhea, gas, heartburn, nausea, vomiting, and dizziness.

    • Get emergency help right away if you get any of the following symptoms:

  • shortness of breath or trouble breathing
  • chest pain
  • weakness in one part or side of your body
  • slurred speech
  • swelling of the face or throat

    • Stop taking Elyxyb and call your healthcare provider right away if you get any of the following symptoms:

  • nausea
  • muscle aches
  • more tired or weaker than usual
  • diarrhea
  • itching
  • your skin or eyes look yellow
  • bruising
  • indigestion or stomach pain
  • flu-like symptoms
  • vomit blood
  • there is blood in your bowel movement or it is black and sticky like tar
  • unusual weight gain
  • skin rash or blisters with fever
  • swelling of the arms, legs, hands and feet

    • These are not all the possible side effects of NSAIDs. For more information, ask your healthcare provider or pharmacist about NSAIDs. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Other information about NSAIDs

    Aspirin is an NSAID but it does not increase the chance of a heart attack. Aspirin can cause bleeding in the brain, stomach, and intestines. Aspirin can also cause ulcers in the stomach and intestines.

    Some NSAIDs are sold in lower doses without a prescription (over-the counter). Talk to your healthcare provider before using over­ the-counter NSAIDs for more than 10 days.

    Before taking Elyxyb

    Tell your doctor if you are pregnant or plan to become pregnant. Taking NSAIDs, including Elyxyb, at about 20 weeks of pregnancy or later may harm your unborn baby. If you need to take NSAIDs for more than 2 days when you are between 20 and 30 weeks of pregnancy, your healthcare provider may need to monitor the amount of fluid in your womb around your baby. You should not take NSAIDs after about 30 weeks of pregnancy.

    Tell your doctor if you are breastfeeding or plan to breast feed. Elyxyb may pass into your breast milk. Talk with your healthcare provider about the best way to feed your baby if you take Elyxyb.

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    How to use Elyxyb

  • The recommended dose of Elyxyb is 120 mg taken orally, with or without food.
  • The recommended dose of Elyxyab is 60 mg for people with moderate liver impairment or who are poor metabolizers of CYP2CP substrates.
  • The maximum dosage in a 24-hour period is 120 mg.

    • See full prescribing information for further information about Elyxyb dosing.

    Warnings

    Elyxyb contains the NSAID celecoxib. NSAIDs, including Elyxyb, can cause serious side effects, including:

  • Increased risk of a heart attack or stroke that can lead to death. This risk may happen early in treatment and may increase:
  • with increasing doses of NSAIDs
  • with longer use of NSAIDs

    • Do not take Elyxyb right before or after a heart surgery called a coronary artery bypass graft (CABG).

    Avoid taking NSAIDs, including Elyxyb, after a recent heart attack, unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack.

  • Increased risk of bleeding, ulcers, and tears (perforation) of the esophagus (tube leading from the mouth to the stomach), stomach and intestines:
  • anytime during use
  • without warning symptoms
  • that may cause death

    • The risk of getting an ulcer or bleeding increases with:

  • past history of stomach ulcers, or stomach or intestinal bleeding with use of NSAIDs
  • taking medicines called corticosteroids, antiplatelet drugs, anticoagulants, selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs)
  • increasing doses of NSAIDs
  • longer use of NSAIDs
  • smoking
  • drinking alcohol
  • older age
  • poor health
  • advanced liver disease
  • bleeding problems

    • Elyxyb should only be used:

  • exactly as prescribed
  • for the shortest time needed

    • What other drugs will affect Elyxyb

    Tell your healthcare provider about all of the medicines you take, including prescription or over-the-counter medicines, vitamins or herbal supplements. NSAIDs, including Elyxyb, and some other medicines can interact with each other and cause serious side effects. Do not start taking any new medicine without talking to your healthcare provider first.

    Especially tell your doctor if you take:

  • Corticosteroids
  • Antiplatelet and anticoagulant drugs such as warfarin and aspirin
  • SSRIs
  • SNRIs
  • Ace inhibitors, angiotensin receptor blockers or beta blockers
  • Diurectics
  • Digoxin
  • Other NSAIDs

    • If you are not sure if you take one of these medications then check with your doctor or pharmacist.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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