Empagliflozin, linagliptin, and metformin
Generic name: Empagliflozin, Linagliptin, And Metformin
Brand names: Trijardy XR
Dosage form: oral tablet, extended release (10 mg-5 mg-1000 mg; 12.5 mg-2.5 mg-1000 mg; 25 mg-5 mg-1000 mg; 5 mg-2.5 mg-1000 mg)
Drug class:
Antidiabetic combinations
Usage of Empagliflozin, linagliptin, and metformin
Empagliflozin, linagliptin, and metformin (Trijardy XR) is a combination medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
Trijardy XR is also used to lower the risk of death from heart attack, stroke, or heart failure in adults with type 2 diabetes who also have heart disease.
Trijardy XR is not for treating type 1 diabetes.
Empagliflozin, linagliptin, and metformin may also be used for purposes not listed in this medication guide.
Empagliflozin, linagliptin, and metformin side effects
Get emergency medical help if you have signs of an allergic reaction: hives, itching, flaking or peeling skin; trouble swallowing, difficult breathing; swelling of your face, lips, tongue, or throat.
Seek medical attention right away if you have signs of a serious genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, not feeling well. These symptoms may get worse quickly.
Stop taking empagliflozin, linagliptin, and metformin and call your doctor at once if you have:
Common side effects of empagliflozin, linagliptin, and metformin may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Empagliflozin, linagliptin, and metformin
You should not use empagliflozin, linagliptin, and metformin if you are allergic to empagliflozin, linagliptin, or metformin, or if you have:
If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking this medicine. Be sure your caregivers know ahead of time that you are using Trijardy XR.
Tell your doctor if you have ever had:
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Ask your doctor about your risk.
Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy.
You should not use Trijardy XR during the second or third trimester of pregnancy.
Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.
Do not breastfeed.
Not approved for use by anyone younger than 18 years old.
Relate drugs
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- Ertugliflozin and metformin
- Ertugliflozin and sitagliptin
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- Glucovance
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- Insulin glargine and lixisenatide
- Invokamet
- Invokamet XR
- Janumet
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- Jentadueto
- Jentadueto XR
- Kazano
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- Linagliptin and metformin
- Metaglip
- Metformin and pioglitazone
- Metformin and saxagliptin
- Metformin and sitagliptin
- Oseni
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- Repaglinide and metformin
- Rosiglitazone and glimepiride
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- Saxagliptin and dapagliflozin
- Saxagliptin and metformin
- Segluromet
- Sitagliptin and metformin
- Soliqua
- Soliqua 100/33
- Steglujan
- Synjardy
- Synjardy XR
- Trijardy XR
- Xigduo XR
- Xultophy
How to use Empagliflozin, linagliptin, and metformin
Usual Adult Dose for Diabetes Type 2:
Individualize initial dose based on the patient's current regimen: -For patients on metformin, with or without linagliptin: Initiate with a similar metformin dose plus empagliflozin 10 mg and linagliptin 5 mg orally once a day-For patients on metformin and any regimen containing empagliflozin, with or without linagliptin: Initiate with a similar dose of metformin, the same empagliflozin dose, and linagliptin 5 mg orally once a day Monitor effectiveness and tolerability and adjust dose as appropriate not to exceed maximum doses -Maximum doses: Empagliflozin 25 mg/day; Linagliptin 5 mg/day; Metformin 2000 mg/dayComments:-When used in combination with insulin or an insulin secretagogue, a lower dose of insulin or insulin secretagogue should be considered to reduce the risk of hypoglycemia.-Correct volume depletion prior to beginning therapy.-This drug is not recommended in patients with type 1 diabetes mellitus; it may increase the risk of ketoacidosis in these patients. -This drug has not been studied in patients with a history of pancreatitis and therefore it is unknown if patients with a history of pancreatitis are at an increased risk for developing pancreatitis while using this drug. Uses: -As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. -Empagliflozin is indicated to reduce the risk of cardiovascular (CV) death in adults with type 2 diabetes mellitus and established CV disease.
Warnings
Stop taking this medicine and call your doctor at once if you have signs of a serious side effect, such as severe stomach pain (may spread to your back), vomiting, tiredness, or trouble breathing.
Tell your doctor if you are sick with vomiting or diarrhea, or if you eat or drink less than usual.
Get emergency medical help if you have symptoms of lactic acidosis such as unusual muscle pain, trouble breathing, irregular heartbeats, or if you feel very weak.
This medicine can cause serious infections around the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.
What other drugs will affect Empagliflozin, linagliptin, and metformin
Other drugs may increase or decrease the effects of empagliflozin, linagliptin, and metformin on lowering your blood sugar. Tell your doctor about all your current medicines and any you start or stop using, especially:
This list is not complete. Other drugs may affect empagliflozin, linagliptin, and metformin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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