Enalapril

Generic name: Enalapril (oral/injection)
Drug class: Angiotensin Converting Enzyme Inhibitors

Usage of Enalapril

Enalapril oral is used alone or in combination with other medications to treat high blood pressure in adults and children at least 1 month old.

Enalapril oral can also be used to prevent and treat congestive congestive heart failure in adults.

Enalapril injection is used in adults to treat high blood pressure.

Enalapril belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors. It works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.

Enalapril side effects

Get emergency medical help if you have signs of an allergic reaction to enalapril: hives, severe stomach pain, difficulty breathing, swelling of your face, lips, tongue, or throat.

Enalapril may cause serious side effects. Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

high blood potassium - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement;

low white blood cell counts - fever, mouth sores, skin sores, sore throat, cough;

kidney problems - swelling, urinating less, feeling tired or short of breath; or

liver problems - loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common enalapril side effects may include:

cough, diarrhea;

chest pain, dizziness, tiredness;

headache, nausea; or

low blood pressure.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Enalapril

You should not use enalapril if you are allergic to it or to any other ACE (angiotensin converting enzyme) inhibitor such as Benazepril, Captopril, fosinopril, trandolapril, lisinopril, moexipril, perindopril, quinapril, or ramipril.

Do not use enalapril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

Do not use enalapril if you have a history of angioedema (severe allergic reaction).

If you have diabetes, do not use enalapril together with any medication that contains aliskiren (a blood pressure medicine).

To make sure this medicine is safe for you, tell your doctor if you have ever had:

heart disease, heart problems such as a recent heart attack;

low blood pressure;

stomach pain;

low white blood cell count;

if you are on a low-salt diet;

diabetes;

kidney disease (or if you are on dialysis); or

liver disease.

You may also need to avoid taking enalapril with aliskiren if you have kidney disease.

Stop using this medicine and tell your doctor right away if you become pregnant. Enalapril can cause injury or death to the unborn baby if you use the medicine during your second or third trimester.

Do not breastfeed.

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How to use Enalapril

Usual Adult Dose for Hypertension:

Initial dose (oral tablets or solution): 5 mg orally once a day Maintenance dose (oral tablets or solution): 10 to 40 mg orally per day as a single dose or in 2 divided doses Maximum dose: 40 mg orally daily as a single dose or in 2 divided doses In combination with diuretics: Initial dose: 2.5 mg orally once a day If feasible, the diuretic should be discontinued 2 to 3 days prior to initiation of therapy with enalapril. If required, diuretic therapy may be gradually resumed. Parenteral: 1.25 to 5 mg IV over a 5 minute period every 6 hours Comments: -Clinical response is usually seen within 15 minutes after IV administration. -If required, diuretic therapy may be gradually resumed.

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 2.5 mg orally once a day Maintenance dose: 2.5 to 20 mg daily in 2 divided doses Maximum dose: 40 mg orally per day in 2 divided doses Comments: -Treatment is usually combined with diuretics and digitalis. -Doses should be titrated upward, as tolerated, over a period of a few days or weeks.

Usual Adult Dose for Left Ventricular Dysfunction:

Initial dose: 2.5 mg orally twice a day Maintenance dose: 20 mg orally per day in 2 divided doses Comments: -After the initial dose, the patient should be observed for at least 2 hours and until blood pressure has stabilized for at least an additional hour. -If possible, the dose of any concomitant diuretic should be reduced which may diminish the likelihood of hypotension.

Usual Pediatric Dose for Hypertension:

Oral tablets or solution: Children 1 month to 17 years: Initial dose: 0.08 mg/kg/day (up to 5 mg) in 1 to 2 divided doses. Adjust dosage based on patient response. Maximum dose: Doses greater than 0.58 mg/kg (40 mg) have not been evaluated in pediatric patients. Comment: -Not recommended in neonates and in pediatric patients with glomerular filtration rate less than 30 mL/min, as no data are available.

Warnings

Do not use enalapril if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

Tell your doctor about all your other medicines. Some drugs should not be used with enalapril.

If you have diabetes, do not use enalapril together with any medication that contains aliskiren (such as Tekturna or Tekamlo).

You should not use enalapril if you have ever had angioedema. Do not take this medicine within 36 hours before or after taking any medicine that contains sacubatril (such as Entresto).

Enalapril can affect your heart or your electrolyte levels. Call your doctor if you have chest pain, pounding heartbeats or fluttering in your chest, a slow heart rate or weak pulse, a tingly feeling, muscle weakness, or muscle tightness or contraction.

What other drugs will affect Enalapril

Enalapril can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis.

Tell your doctor about all your other medicines, especially:

a diuretic or "water pill" that may increase blood potassium such as spironolactone, triamterene, amiloride;

NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), Celecoxib, Diclofenac, indomethacin, Meloxicam, and others;

medicine to prevent organ transplant rejection such as temsirolimus, sirolimus, or everolimus; or

heart or blood pressure medication.

This list is not complete. Other drugs may interact with enalapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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