Entrectinib

Generic name: Entrectinib
Brand names: Rozlytrek
Dosage form: oral capsule (100 mg; 200 mg)
Drug class: Multikinase inhibitors

Usage of Entrectinib

Entrectinib is used in adults to treat non-small cell lung cancer that has spread to other parts of the body (metastatic).

Entrectinib is also used in adults and children at least 12 years old who have solid tumors that have spread or cannot be safely removed with surgery, or when other treatments have failed or are not safe options.

Entrectinib is used only if your cancer has a specific abnormal gene. Your doctor will test you for this gene.

Entrectinib may also be used for purposes not listed in this medication guide.

Entrectinib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Entrectinib may cause serious side effects. Call your doctor at once if you have:

bone pain or problems moving;

fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

nausea, vomiting, loss of appetite, right-sided upper stomach pain;

swelling in your lower legs, rapid weight gain;

cough, wheezing, shortness of breath, trouble breathing while lying down;

confusion, hallucinations, problems with memory or concentration;

dizziness, mood changes, trouble sleeping; or

blurred vision, double vision, increased sensitivity to light, or seeing flashes of light or "floaters" in your vision.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of entrectinib may include:

changes in your mental status;

vision changes;

nausea, vomiting, diarrhea, constipation;

fever, cough;

dizziness, tiredness;

weight gain, swelling;

muscle or joint pain;

trouble breathing; or

changes in your sense of taste or touch.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Entrectinib

Tell your doctor if you have ever had:

gout;

heart problems;

long QT syndrome (in you or a family member);

liver or kidney disease;

a nervous system disorder; or

problems with your eyes or vision.

You may need to have a negative pregnancy test before starting this treatment.

Entrectinib can harm an unborn baby or cause birth defects if the mother or the father is using entrectinib.

If you are a woman, do not use entrectinib if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 5 weeks after your last dose.

If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using entrectinib.

Do not breastfeed while using this medicine, and for at least 7 days after your last dose.

Relate drugs

How to use Entrectinib

Usual Adult Dose for Non-Small Cell Lung Cancer:

600 mg orally once a day until disease progression or unacceptable toxicityUse: For adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are ROS1-positive

Usual Adult Dose for Solid Tumors:

600 mg orally once a day until disease progression or unacceptable toxicityUses: For adult patients with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation; are metastatic or where surgical resection is likely to result in severe morbidity; and have progressed following treatment or have no satisfactory alternative therapy.

Usual Pediatric Dose for Solid Tumors:

12 years and older:-Body surface area (BSA) greater than 1.5 m2: 600 mg orally once a day-BSA 1.11 to 1.5 m2: 500 mg orally once a day-BSA 0.91 to 1.1 m2: 400 mg orally once a dayUse: For pediatric patients 12 years and older with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation; are metastatic or where surgical resection is likely to result in severe morbidity; and have progressed following treatment or have no satisfactory alternative therapy.

Warnings

Entrectinib may cause new or worsened symptoms of congestive heart failure. Call your doctor at once if you have swelling in your lower legs, rapid weight gain, cough, wheezing, shortness of breath, or trouble breathing while lying down.

What other drugs will affect Entrectinib

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect entrectinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.