Ertugliflozin and sitagliptin

Generic name: Ertugliflozin And Sitagliptin
Brand names: Steglujan
Dosage form: oral tablet (15 mg-100 mg; 5 mg-100 mg)
Drug class: Antidiabetic combinations

Usage of Ertugliflozin and sitagliptin

Ertugliflozin and sitagliptin is a combination medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. ertugliflozin and sitagliptin is not for treating type 1 diabetes.

Ertugliflozin and sitagliptin may also be used for purposes not listed in this medication guide.

Ertugliflozin and sitagliptin side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical attention right away if you have signs of a rare but serious genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, not feeling well. These symptoms may get worse quickly.

Ertugliflozin and sitagliptin may cause serious side effects. Call your doctor at once if you have:

severe autoimmune reaction--itching, blisters, breakdown of the outer layer of skin;

new pain, tenderness, sores, ulcers, or infections in your legs or feet;

severe or ongoing pain in your joints;

little or no urination;

ketoacidosis (too much acid in the blood)--nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing;

dehydration symptoms--dizziness, weakness, feeling light-headed (like you might pass out);

signs of a bladder infection--pain or burning when you urinate, increased urination, blood in your urine, fever, pain in your pelvis or back;

symptoms of heart failure--shortness of breath (even while lying down), swelling in your legs or feet, rapid weight gain; or

symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, with or without nausea and vomiting.

Some side effects may be more likely to occur in older adults.

Common side effects of ertugliflozin and sitagliptin may include:

urinating more than usual;

upset stomach, diarrhea;

headache; or

cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Ertugliflozin and sitagliptin

You should not use this medicine if you are allergic to ertugliflozin o sitagliptin, or if you have:

severe kidney problems, end stage renal disease, or if you are on dialysis.

Tell your doctor if you have ever had:

diabetic ketoacidosis;

liver or kidney disease;

a bladder infection or urination problems;

problems with your pancreas, including surgery;

a diabetic foot ulcer or amputation;

heart problems, high or low blood pressure;

blood circulation problems, especially in your legs;

nerve damage in your legs;

gallstones;

high triglycerides (a type of fat in blood);

alcoholism;

type 1 diabetes; or

if you are eating less, there is a change in your diet, or you are on a low salt diet.

Follow your doctor's instructions about using this medicine if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester.

You should not use ertugliflozin and sitagliptin during the second or third trimester of pregnancy.

You should not breastfeed while using this medicine.

Ertugliflozin and sitagliptin is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Ertugliflozin and sitagliptin

Usual Adult Dose for Diabetes Type 2:

Initial dose: 1 tablet (ertugliflozin 5 mg/sitagliptin 100 mg) orally once a day -For patients tolerating therapy and requiring additional glycemic control, may increase to 1 tablet (ertugliflozin 15 mg/sitagliptin 100 mg) orally once a dayMaximum dose: ertugliflozin 15 mg/sitagliptin 100 mg per dayFor patients already receiving ertugliflozin: Switch to combination product with same ertugliflozin doseComments:-Volume depletion should be corrected prior to initiating therapy. -This drug is not recommended for patients with type 1 diabetes mellitus as it may increase the risk of diabetic ketoacidosis in these patients. -This drug has not been studied in patients with a history of pancreatitis; it is not known whether this may increase the risk of developing pancreatitis during therapy. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Warnings

Stop taking ertugliflozin and sitagliptin and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, with or without nausea and vomiting.

In rare cases, ertugliflozin and sitagliptin can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.

What other drugs will affect Ertugliflozin and sitagliptin

When you start or stop taking ertugliflozin and sitagliptin, your doctor may need to adjust the doses of any other diabetes medicines you use on a regular basis.

Other drugs may affect ertugliflozin and sitagliptin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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