Erythromycin (EENT)
Drug class: Antineoplastic Agents
Usage of Erythromycin (EENT)
Bacterial Ophthalmic Infections
Topical treatment of superficial infections of the eye involving the conjunctiva and/or cornea caused by susceptible bacteria.
Mild, acute bacterial conjunctivitis often resolves spontaneously without anti-infective treatment. Although topical ophthalmic anti-infectives may shorten time to resolution and reduce severity and risk of complications, avoid indiscriminate use of topical anti-infectives.
Treatment of acute bacterial conjunctivitis generally is empiric; use of a broad-spectrum topical ophthalmic antibacterial usually recommended. In vitro staining and/or cultures of conjunctival material indicated in diagnosis and management of all cases of suspected infectious conjunctivitis in neonates, all cases of suspected gonococcal or chlamydial conjunctivitis, and may be indicated in management of recurrent, severe, or chronic purulent conjunctivitis or when acute conjunctivitis does not respond to initial empiric topical treatment.
Bacterial conjunctivitis caused by Neisseria gonorrhoeae requires treatment with systemic anti-infectives (e.g., IM or IV ceftriaxone) with or without topical anti-infectives. Topical anti-infectives alone are inadequate for treatment of ophthalmia neonatorum caused by N. gonorrhoeae; some experts state that adjunctive use of topical anti-infectives unnecessary when appropriate systemic anti-infectives used.
Chlamydial Ophthalmic Infections
Has been used topically in the treatment of conjunctivitis secondary to trachoma caused by Chlamydia trachomatis† [off-label]; however, systemic anti-infectives (usually oral azithromycin) are recommended for treatment of ocular trachoma.
Systemic anti-infectives (e.g., oral azithromycin, doxycycline, or erythromycin) are necessary for treatment of chlamydial conjunctivitis, including chlamydial ophthalmia neonatorum. Experts state that topical anti-infectives alone are inadequate for treatment of chlamydial ophthalmic infections and are unnecessary when appropriate systemic anti-infectives used.
Has been used for topical prophylaxis of ophthalmia neonatorum caused by C. trachomatis. However, efficacy of topical prophylaxis for prevention of chlamydial neonatal conjunctivitis not established. Experts state that erythromycin used for topical prophylaxis of gonococcal ophthalmia neonatorum will not prevent chlamydial ophthalmia neonatorum.
Prophylaxis of Gonococcal Ophthalmia Neonatorum
Topical prophylaxis of ophthalmia neonatorum caused by N. gonorrhoeae. Efficacy for prevention of ophthalmia neonatorum caused by penicillinase-producing N. gonorrhoeae not established.
CDC and AAP recommend topical erythromycin prophylaxis in all neonates as soon as possible after birth (regardless of whether they are delivered vaginally or by cesarean section); such prophylaxis required by law in most states. Although silver nitrate and tetracycline have been used in the past for topical prophylaxis of gonococcal ophthalmia neonatorum, ophthalmic preparations of these drugs no longer commercially available in the US.
If erythromycin ophthalmic ointment not available, CDC recommends systemic prophylaxis with a single dose of ceftriaxone (IM or IV) for all neonates at risk for exposure to N. gonorrhoeae (especially those born to women who are at risk for gonococcal infection or received no prenatal care).
Infants born to women with untreated gonorrhea are at high risk of infection; CDC and AAP recommend that such neonates receive systemic prophylaxis with a single dose of ceftriaxone (IM or IV) instead of topical erythromycin prophylaxis.
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How to use Erythromycin (EENT)
Administration
Ophthalmic Administration
Apply 0.5% ophthalmic ointment topically to the eye.
For topical ophthalmic use only.
Avoid contaminating tip of ointment tube with material from eye, fingers, or other source.
When used for prophylaxis of gonococcal ophthalmia neonatorum, place specified amount of ointment into each of neonate’s lower conjunctival sacs and massage gently to spread ointment; after 1 minute, wipe away excess ointment with sterile cotton. Do not flush ointment from the eye following application. Use a new tube or single-use container of ointment for each neonate.
Dosage
Pediatric Patients
Bacterial Ophthalmic Infections OphthalmicApply 1-cm ribbon of 0.5% ointment to the affected eye(s) up to 6 times daily. For empiric treatment of acute bacterial conjunctivitis, experts recommend application 4 times daily for 1 week.
Prophylaxis of Gonococcal Ophthalmia Neonatorum OphthalmicPlace 1-cm ribbon of 0.5% ointment into lower conjunctival sac of both eyes.
Administer as soon as possible (within 1 hour) after birth. Efficacy unlikely to be affected if topical prophylaxis delayed for up to 1 hour after delivery (e.g., to facilitate parent-infant bonding); efficacy of prophylaxis administered after a longer delay not studied.
Adults
Bacterial Ophthalmic Infections OphthalmicApply 1-cm ribbon of 0.5% ointment to the affected eye(s) up to 6 times daily. For empiric treatment of acute bacterial conjunctivitis, experts recommend application 4 times daily for 1 week.
Warnings
Contraindications
Warnings/Precautions
Sensitivity Reactions
HypersensitivityPossible sensitivity reactions.
General Precautions
SuperinfectionProlonged use may result in overgrowth of nonsusceptible organisms, including fungi.
If superinfection occurs, discontinue and institute appropriate therapy.
Specific Populations
PregnancyData not available regarding use in pregnant women. Use only if clearly needed.
LactationUse with caution in nursing women.
Pediatric UseSee Uses.
Geriatric UseNo overall differences in safety or efficacy compared with younger patients.
Common Adverse Effects
Minor ocular irritation, redness, hypersensitivity.
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