Etelcalcetide

Generic name: Etelcalcetide
Brand names: Parsabiv
Dosage form: intravenous solution (5 mg/mL)
Drug class: Calcimimetics

Usage of Etelcalcetide

EtelCalcetide is used to treat overactive parathyroid gland (hyperparathyroidism) in adults with chronic kidney failure who are on dialysis.

Etelcalcetide may also be used for purposes not listed in this medication guide.

Etelcalcetide side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Etelcalcetide may cause serious side effects. Call your doctor at once if you have:

a seizure (convulsions);

shortness of breath (even with mild exertion), swelling, rapid weight gain;

irregular heartbeats;

low calcium levels--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes); or

signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects of etelcalcetide may include:

numbness or tingling;

muscle spasms;

low calcium;

headache; or

nausea, vomiting, diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Etelcalcetide

You should not be treated with etelcalcetide if you are allergic to it.

Tell your doctor if you have ever had:

congestive heart failure;

stomach or intestinal bleeding;

a seizure;

long QT syndrome (in you or a family member); or

if you have used cinacalcet (Sensipar) within the past 7 days.

It is not known whether etelcalcetide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast-feed while using this medicine.

Relate drugs

How to use Etelcalcetide

Usual Adult Dose for Secondary Hyperparathyroidism:

Initial dose: 5 mg IV 3 times per week -Adjust dose in increments of 2.5 or 5 mg no more frequently than every 4 weeks to achieve a dose that maintains parathyroid hormone levels within the target range and corrected serum calcium within the normal rangeMaintenance dose: 2.5 to 15 mg IV 3 times per week Comments:-If switching from cinacalcet, discontinue cinacalcet at least 7 days prior to starting this drug. -Ensure corrected serum calcium is at or above the lower limit of normal prior to initiating therapy; a dose increase, or re-initiation after a dose interruption. -Dose should be administered by IV bolus at the end of hemodialysis treatment.-If a hemodialysis treatment is missed, do not give this drug; resume this drug at the end of the next hemodialysis session at the prescribed dose; if more than 2 weeks of hemodialysis treatments are missed, reinitiate this drug at the recommended starting dose (5 mg) or 2.5 mg if that was the patient's last dose. Use: For the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on hemodialysis.

Warnings

Before you receive etelcalcetide, tell your doctor if you have taken cinacalcet within the past 7 days.

What other drugs will affect Etelcalcetide

Other drugs may affect etelcalcetide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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