Exforge HCT

Generic name: Amlodipine, Hydrochlorothiazide, And Valsartan
Drug class: Miscellaneous antihypertensive combinations

Usage of Exforge HCT

Exforge HCT contains a combination of amlodipine, hydrochlorothiazide, and valsartan. Amlodipine is a calcium channel blocker that relaxes (widens) blood vessels and improves blood flow.

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Valsartan is an angiotensin II receptor antagonist (sometimes called an ARB) that keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Exforge HCT is used to treat high blood pressure (hypertension).

Exforge HCT is usually given after other blood pressure medicines have been tried without successful treatment of symptoms.

Exforge HCT side effects

Get emergency medical help if you have signs of an allergic reaction to Exforge HCT: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

an unusual skin rash;

blurred vision, tunnel vision, eye pain, or seeing halos around lights;

high or low potassium levels - leg cramps, nausea, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;

kidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath;

low magnesium level - dizziness, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling; or

low sodium level - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Common Exforge HCT side effects may include:

dizziness;

headache, tiredness;

nausea, upset stomach;

stuffy nose, sinus pain, sore throat;

back pain, muscle spasms; or

swelling in your hands, ankles, or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Exforge HCT

You should not use Exforge HCT if you are allergic to amlodipine, hydrochlorothiazide, or valsartan, or:

if you are allergic to any sulfa drug; or

if you are unable to urinate.

If you have diabetes, do not use Exforge HCT together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking Exforge HCT with aliskiren if you have kidney disease.

To make sure Exforge HCT is safe for you, tell your doctor if you have ever had::

heart problems;

an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);

high blood levels of calcium;

kidney disease (or if you are on dialysis);

liver disease;

glaucoma;

gout, or increased uric acid in your blood;

lupus;

gallstones; or

a penicillin allergy.

Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Valsartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breastfeed while using Exforge HCT.

Relate drugs

How to use Exforge HCT

Usual Adult Dose for Hypertension:

Initial dose: 1 tablet orally once a day (The dosage may be increased after 2 weeks of therapy. The full blood pressure lowering effect was achieved 2 weeks after being on the maximal dose) Maximum dose: Amlodipine/hydrochlorothiazide/valsartan 10 mg/25 mg/320 mg orally once a day Comment: -Indicated for patients whose blood pressure is adequately controlled on amlodipine, valsartan, and hydrochlorothiazide (as single component formulations or a dual component formulation with a single component formulation). Individual dose titration with each component is recommended before administering the fixed dose combination.

Warnings

You should not take Exforge HCT if you are allergic to sulfa drugs, or if you are unable to urinate.

Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant.

If you have diabetes, do not use Exforge HCT together with any medication that contains aliskiren (a blood pressure medicine).

What other drugs will affect Exforge HCT

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect Exforge HCT, especially:

another a diuretic or "water pill";

any other blood pressure medicines;

insulin or oral diabetes medicine;

steroid medicine;

vitamin or mineral supplements that contain potassium;

a sedative or opioid medicine;

cholesterol-lowering medicine;

an antibiotic, antifungal, or antiviral medicine; or

NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), and others.

This list is not complete and many other drugs may interact with amlodipine, hydrochlorothiazide, and valsartan. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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