Eysuvis

Generic name: Loteprednol Etabonate
Dosage form: eye (suspension) drops
Drug class: Ophthalmic steroids

Usage of Eysuvis

Eysuvis (loteprednol etabonate) is a prescription corticosteroid eye drop used for the short-term treatment of dry eye disease.

People with dry eye disease make poor quality tears or not enough tears, which can cause red, burning and scratchy eyes. It can also cause eyes to become teary and result in blurred vision.

Eysuvis works by blocking inflammation, which is a key driver of dry eye flare-ups.

Eysuvis is a suspension eye drop that makes use of a drug delivery technology called Ampplify, which allows the medication to better penetrate the mucus barrier on your eyes, leading to increased amounts of the corticosteroid medication reaching the affected area.

Eysuvis was the first corticosteroid eye drop to be approved by the US Food and Drug Administration (FDA) for the short-term treatment of dry eye disease when it was approved in 2020.

Eysuvis side effects

Eysuvis may cause serious side effects. See "Important information" above.

The most common side effect of Eysuvis after using it for two weeks was instillation site pain, which was reported in 5 percent of patients.

This is not the only possible side effect of Eysuvis. Call your doctor for advice about side effects.

To report suspected adverse reactions, contact Kala Pharmaceuticals, Inc. at 1-833-287-KALA (1-833-287-5252) or FDA at 1-800-FDA-1088 or. www.fda.gov/medwatch.

Before taking Eysuvis

Tell your doctor if you are pregnant or plan to become pregnant. Eysuvis should only be used during pregnancy if the benefit outweighs the risk to the fetus.

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if Eysuvis passes into your breast milk. Talk to your doctor about the best way to feed your baby if you use Eysuvis.

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How to use Eysuvis

The recommended dose of Eysuvis is 1 to 2 drops into each eye four times daily for up to two weeks.

Warnings

Eysuvis is for use in the eyes.

Eysuvis may cause serious side effects.

  • Intraocular pressure (IOP) increase
  • Prolonged use of ophthalmic corticosteroids can cause an increase in the pressure in your eyes and may result in glaucoma and damage to your eyes. Your doctor should examine your eyes before you start using this medication to check for increased eye pressure.
  • Cataracts
  • Use of ophthalmic corticosteroids may result in posterior suBCapsular cataract formation.
  • Delayed healing
  • Use of ophthalmic corticosteroids may delay healing. Your doctor should examine your eyes before you start using this medications and before each renewal of your prescription to check for signs of damage to the surface of your eyes.
  • Viral infections
  • Ophthalmic corticosteroids may prolong viral eye infections and make them more severe. Use of ocular steroids should not be used in most viral eye infections and should be used with great caution in people with a history of herpes simplex.
  • Bacterial infections
  • Ophthalmic corticosteroids should not be used in mycobacterial infection of the eye. They may also suppress your immune response increases your chances of a secondary infection, mask an infection or enhance an existing infection.
  • Fungal infections
  • Long-term use of corticosteroid eye drops can increase your chances of a fungal infection of the cornea. Persistent corneal ulceration when using corticosteroid eye drops may be a sign of a fungal infection.

    • Remove contact lenses before using Eysuvis. Contact lenses may be reinserted 15 minutes later.

    What other drugs will affect Eysuvis

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

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