Fam-trastuzumab deruxtecan
Generic name: Fam-trastuzumab Deruxtecan
Brand names: Enhertu
Dosage form: intravenous powder for injection (nxki 100 mg)
Drug class:
HER2 inhibitors
Usage of Fam-trastuzumab deruxtecan
Fam-trastuzumab deruxtecan is used in adults to treat HER2-positive breast cancer that has spread to other parts of the body (metastatic) or cannot be removed with surgery.
Fam-trastuzumab deruxtecan is also used in adults who have received an anti-HER2 breast cancer treatment before for metastatic diseases, or have breast cancer that has come back within 6 months of completing treatment for early stages breast cancer.
Fam-trastuzumab deruxtecan can also used in adults to treat a certain type of HER2-positive esophageal cancer.
Fam-trastuzumab deruxtecan is usually given after other cancer treatments did not work or have stopped working.
Fam-trastuzumab deruxtecan may also be used for purposes not listed in this medication guide.
Fam-trastuzumab deruxtecan side effects
Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Fam-trastuzumab deruxtecan may cause serious side effects. Call your doctor at once if you have:
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects of fam-trastuzumab deruxtecan may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Fam-trastuzumab deruxtecan
Tell your doctor if you have ever HAD:
You may need to have a negative pregnancy test before starting this treatment.
Fam-trastuzumab deruxtecan can harm an unborn baby if the mother or the father is using this medicine.
This medicine may affect fertility (ability to have children), in men.
Do not breastfeed while using this medicine, and for at least 7 months after your last dose.
Relate drugs
- Ado-trastuzumab emtansine
- Enhertu
- Fam-trastuzumab deruxtecan
- Fam-trastuzumab deruxtecan-nxki
- Herceptin
- Herceptin Hylecta
- Herzuma
- Herzuma (Trastuzumab Intravenous)
- Herzuma (Trastuzumab-pkrb Intravenous)
- Hyaluronidase and trastuzumab
- Hyaluronidase, pertuzumab, and trastuzumab
- Kadcyla
- Margenza
- Margetuximab
- Margetuximab-cmkb
- Ogivri
- Ogivri (Trastuzumab Intravenous)
- Ogivri (Trastuzumab-dkst Intravenous)
- Ontruzant
- Ontruzant (Trastuzumab Intravenous)
- Ontruzant (Trastuzumab-dttb Intravenous)
- Perjeta
- Pertuzumab
- Pertuzumab, trastuzumab, and hyaluronidase-zzxf
- Phesgo
- Trastuzumab
- Trastuzumab and hyaluronidase-oysk
- Trastuzumab-anns
- Trastuzumab-dkst
- Trastuzumab-dttb
- Trastuzumab-pkrb
- Trazimera
- Tucatinib
- Tukysa
How to use Fam-trastuzumab deruxtecan
Usual Adult Dose for Breast Cancer:
5.4 mg/kg IV every 3 weeks (21-Day cycle) until disease progression or uNACceptable toxicityComments:-Administer the first infusion over 90 minutes; administer subsequent infusions over 30 minutes if prior infusions were well tolerated.-Slow or interrupt the infusion rate if the patient develops infusion-related symptoms.-Permanently discontinue therapy for severe infusion reactions.Use: For the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received 2 or more prior anti-HER2-based regimens in the metastatic setting
Warnings
Fam-trastuzumab deruxtecan can cause serious or life-threatening side effects on your heart or lungs. Call your doctor right away if you have a cough, tiredness, dizziness, chest tightness, wheezing, irregular heartbeats, new or worsening shortness of breath.
Fam-trastuzumab deruxtecan can weaken (suppress) your immune system, and you may get an infection or bleed more easily. Tell your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, weakness, cold or flu symptoms, frequent or recurring illness).
Both men and women using fam-trastuzumab deruxtecan should use effective birth control to prevent pregnancy. Birth control should be continued for 7 months after the last dose of fam-trastuzumab deruxtecan in women and 4 months after in men.
What other drugs will affect Fam-trastuzumab deruxtecan
Other drugs may affect fam-trastuzumab deruxtecan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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