Febuxostat

Generic name: Febuxostat
Brand names: Uloric
Dosage form: oral tablet (40 mg; 80 mg)
Drug class: Antihyperuricemic agents

Usage of Febuxostat

Febuxostat reduces the production of uric acid in your body. A build-up of uric acid can cause gout symptoms.

Febuxostat is used to keep uric acid levels from getting to high in people with gout.

Febuxostat is for use only in people who cannot take another medicine called allopurinol, or when allopurinol has stopped working.

Febuxostat may also be used for purposes not listed in this medication guide.

Febuxostat side effects

Get emergency medical help if you have signs of an allergic Reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Febuxostat may cause serious side effects. Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, fast heartbeats, shortness of breath;

liver problems--stomach pain (upper right side), unusual tiredness, dark urine, jaundice (yellowing of the skin or eyes); or

signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Common side effects of febuxostat may include:

gout flares, joint pain;

nausea;

mild rash; or

liver problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Febuxostat

You should not use febuxostat if you are allergic to it, or if you also use:

azathioprine; or

Mercaptopurine.

Taking febuxostat may increase your risk of serious or fatal heart problems. Talk with your doctor about the risks and benefits of febuxostat.

Tell your doctor if you have ever had:

heart problems;

a heart attack or stroke;

liver or kidney disease;

cancer;

Lesch-Nyhan syndrome; or

an organ transplant (kidney, liver, lung, heart).

Tell your doctor if you are pregnant or breastfeeding.

Relate drugs

How to use Febuxostat

Usual Adult Dose for Gout:

Initial dose: 40 mg orally once a day-If serum uric acid level is greater than 6 mg/dL after 2 weeks, increase the dose to 80 mg orally once a dayMaintenance dose: 40 to 80 mg orally once a dayMaximum dose: 80 mg/dayComments:-Use of this drug should occur after an acute gout flare subsides.-Gout flares may occur due to increased urate mobilization from tissue deposits, especially during initiation; gout flare prophylaxis with a NSAID or colchicine is recommended and may be beneficial for up to 6 months.-Uric acid levels may be checked as soon as 2 weeks after beginning this drug.Use: For the chronic management of hyperuricemia in patients with gout who have an inadequate experience to a maximally titrated dose of allopurinol, who are intolerant to allopurinol, or for whom treatment with allopurinol is not advisable.

Warnings

Taking febuxostat may increase your risk of serious or fatal heart problems. Seek medical attention if you have chest pain, trouble breathing, fast heartbeats, sudden severe headache, numbness or weakness on one side of your body, or problems with vision or speech.

You should not use febuxostat if you also use azathioprine or mercaptopurine.

What other drugs will affect Febuxostat

Tell your doctor about all your other medicines, especially:

theophylline.

This list is not complete. Other drugs may affect febuxostat, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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