Fingolimod
Generic name: Fingolimod
Drug class:
Selective immunosuppressants
Usage of Fingolimod
Fingolimod is used in adults and children at least 10 years old to treat relapsing forms of multiple sclerosis (including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease).
Fingolimod may also be used for purposes not listed in this medication guide.
Fingolimod side effects
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Fingolimod may cause a brain infection that can lead to disability or death. Tell your doctor if you have problems with speech, thought, vision, or muscle movement. These symptoms can get worse quickly.
Fingolimod can affect your immune system (even 2 months after you've taken fingolimod). You may get infections more easily, even serious or fatal infections. Call your doctor if you have:
Also call your doctor at once if you have:
Common side effects of fingolimod may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Fingolimod
You should not use fingolimod if you are allergic to it, or if you have:
Some heart rhythm medications can cause unwanted or dangerous effects when used with fingolimod. Your doctor may change your treatment plan if you also use: amiodarone, disopyramide, dofetilide, Flecainide, dronedarone, ibutilide, mexiletine, procainamide, propafenone, quinidine, or sotalol.
Before you take fingolimod, tell your doctor if you have never had chickenpox or received a varicella vaccine (Varivax). You may need to receive the vaccine and then wait 1 month before taking fingolimod.
Make sure you are current on all vaccines before you start taking fingolimod.
Tell your doctor if you have recently received a vaccine, or if you are scheduled to receive a vaccine.
Tell your doctor if you have ever had:
Fingolimod may harm an unborn baby. Do not use if you are pregnant. Use effective birth control while taking fingolimod and for at least 2 months after your last dose. Tell your doctor if you become pregnant.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of fingolimod on the baby.
Ask a doctor if it is safe to breastfeed while taking fingolimod.
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How to use Fingolimod
Usual Adult Dose for Multiple Sclerosis:
0.5 mg orally once a dayComments:-This drug can be taken with or without food.-See DOSE ADJUSTMENTS for recommended pre-dose testing and monitoring recommendations.Use: For relapsing forms of multiple sclerosis (MS)
Usual Pediatric Dose for Multiple Sclerosis:
10 years and older and weighing 40 kg or less:0.25 mg orally once a day10 years and older and weighing more than 40 kg:0.5 mg orally once a dayComments:-This drug can be taken with or without food.-See DOSE ADJUSTMENTS for recommended pre-dose testing and monitoring recommendations.Use: For relapsing forms of multiple sclerosis (MS) in patients 10 years and older
Warnings
You should not use fingolimod if you take certain heart rhythm medicines, or if you've had a serious heart condition in the past 6 months. Serious heart conditions include certain heart rhythm disorders, heart failure, chest pain, heart attack, or stroke.
Fingolimod can slow your heart rate when you start taking it. You will receive your first dose in a setting where your heart rhythm can be monitored. Tell your doctor if you have slow heartbeats, chest pain, shortness of breath, or feel like your heart is skipping beats.
You may get infections more easily, even serious or fatal infections. Call your doctor if you have flu symptoms, cough, night sweats, neck stiffness, confusion, vision problems, increased sensitivity to light, loss of balance or coordination, or weakness on one side of the body. Your risk of infection could last for 2 months after you stop taking this medicine.
You may have increased sensitivity to light, blurred vision, eye pain, or have a blind spot or shadows in the center of your vision, unusual color to your vision, or other vision problems while you are taking fingolimod, which may occur 3 to 4 months after your first dose.
What other drugs will affect Fingolimod
Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.
Fingolimod can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.
Fingolimod can have long lasting effects on your body, especially on your immune system. For 2 months after your last dose, tell any doctor who treats you that you have taken fingolimod.
Tell your doctor about all your current medicines. Many drugs can affect fingolimod, especially:
This list is not complete and many other drugs may affect fingolimod. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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