Fludrocortisone

Generic name: Fludrocortisone
Brand names: Florinef Acetate
Dosage form: oral tablet (0.1 mg)
Drug class: Mineralocorticoids

Usage of Fludrocortisone

Fludrocortisone is a steroid that helps reduce inflammation in the body.

Fludrocortisone is used to treat conditions in which the body does not produce enough of its own steroids, such as Addison's disease, and salt-losing adrenogenital syndrome.

Fludrocortisone may also be used for purposes not listed in this medication guide.

Fludrocortisone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Fludrocortisone may cause serious side effects. Call your doctor at once if you have:

swelling of feet or lower legs, rapid weight gain;

muscle weakness, loss of muscle mass;

blurred vision, tunnel vision, eye pain, or seeing halos around lights;

bloody or tarry stools, coughing up blood;

unusual changes in mood or behavior;

a seizure;

increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;

low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;

pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting; or

increased adrenal gland hormones--weight gain in your face and shoulders, slow wound healing, skin discoloration, thinning skin, increased body hair, tiredness, mood changes, menstrual changes, sexual changes.

Common side effects of fludrocortisone may include:

increased blood pressure;

stomach pain, bloating;

facial redness;

acne, increased sweating;

sleep problems (insomnia);

pitting, scars, or bumps under your skin;

stretch marks; or

increased hair growth of body hair.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Fludrocortisone

You should not use fludrocortisone if you are allergic to it, or if you have a fungal infection anywhere in your body.

Fludrocortisone can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

Tell your doctor if you have ever had:

tuberculosis (or if anyone in your household has tuberculosis);

a thyroid disorder;

heart problems, high blood pressure;

diabetes;

glaucoma or cataracts;

herpes infection of the eyes;

a stomach ulcer;

ulcerative colitis, diverticulitis;

a colostomy or ileostomy;

cirrhosis or other liver disease;

kidney disease;

mental illness or psychosis;

osteoporosis; or

myasthenia gravis.

Tell your doctor if you are pregnant. Taking fludrocortisone during pregnancy may cause adrenal gland problems in the baby. Make sure any doctor caring for your pregnancy or your baby knows you haven taken fludrocortisone during pregnancy.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Fludrocortisone is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Fludrocortisone

Usual Adult Dose for Addison's Disease:

0.1 mg orally per dayMaintenance dose: 0.1 mg orally 3 times a week to 0.2 mg orally per dayComments:-If transient hypertension occurs as a consequence of therapy, dose should be reduced to 0.05 mg per day-Often given concomitantly with cortisone or hydrocortisone.Use: For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease

Usual Adult Dose for Adrenogenital Syndrome:

0.1 to 0.2 mg orally per dayUse: For the treatment of salt-losing adrenogenital syndrome

Warnings

You should not use fludrocortisone if you have a fungal infection anywhere in your body.

What other drugs will affect Fludrocortisone

Tell your doctor about all your current medicines. Many drugs can affect fludrocortisone, especially:

aspirin;

a diuretic or "water pill";

insulin or oral diabetes medicine;

birth control pills or hormone replacement therapy;

an anabolic steroid (such as oxandrolone or oxymetholone);

barbiturates (such as Butabarbital, phenobarbital, or secobarbital);

a blood thinner (such as warfarin, Coumadin, or Jantoven); or

drugs that weaken the immune system such as cancer medicine, steroids, and medicines to prevent organ transplant rejection.

This list is not complete and many other drugs may affect fludrocortisone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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