Flunisolide (EENT)
Drug class: Antineoplastic Agents
Usage of Flunisolide (EENT)
Seasonal and Perennial Rhinitis
Symptomatic treatment of seasonal or perennial rhinitis when conventional therapy with antihistamines or decongestants is ineffective or produces intolerable adverse effects.
Generally provides symptomatic relief of watery rhinorrhea, nasal congestion, sneezing, postnasal drip, and pharyngeal itching; generally does not relieve symptoms of conjunctivitis or those involving the lower respiratory tract
Appears to provide greater symptomatic relief in allergic rhinitis than in nonallergic rhinitis
Serious Otitis Media
Has been used intranasally for the treatment of serous otitis media† [off-label] (eustaChian tube dysfunction, middle ear effusion) in children.
Corticosteroid-dependent Asthma
Although orally inhaled flunisolide is used for the treatment of asthma, the nasal solution is not recommended for this purpose, since the safety of polyethylene glycol in the vehicle of the nasal solution has not been established for this route of administration.
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How to use Flunisolide (EENT)
Administration
Intranasal Administration
Administer by nasal inhalation using a special nasal inhaler.
Avoid contact with the eyes.
Poor clinical response can result from improper drug administration techniques, poor drug penetration (secondary to marked nasal congestion, presence of nasal polyps, or symptoms originating in the nasal sinuses), or localized infections of the nasal mucosa.
Clear nasal passages prior to administration. If nasal passages are blocked, a topical nasal decongestant can be administered 5–15 minutes before intranasal administration during the first 2–3 days of therapy to ensure adequate penetration of the drug and prevent loss from the nasal passages via excess secretions.
Prior to initial use, the nasal inhaler must be assembled and primed.
After assembly is complete, tilt the head slightly forward, insert the spray tip into one nostril, and point the tip toward the inflamed nasal turbinates and away from the nasal septum.
Pump the drug into one nostril while holding the other nostril closed and concurrently inspire through the nose. Repeat procedure for the other nostril.
Advise patients to cleanse the nasal adapter and/or pump in warm water if the holes in the device become clogged. If the nasal inhaler is disassembled for any reason (including the cleansing procedure) or not used for 5 days or longer, it must be primed again prior to use.
Dosage
After priming, nasal inhaler delivers about 25 mcg of flunisolide per metered spray and about 200 metered sprays per 25-mL container.
Adjust dosage according to individual requirements and response.
Therapeutic effects of intranasal corticosteroids, unlike those of decongestants, are not immediate. This should be explained to the patient in advance to ensure compliance and continuation of the prescribed treatment regimen.
Symptomatic relief is usually evident within 2–3 days of continuous therapy; however, occasionally, up to 2–3 weeks may be required for optimum effectiveness.
Generally assess response to the initial dosage 4–7 days after starting therapy; about two-thirds will experience some relief within this time period.
Once symptoms of seasonal or perennial rhinitis have been controlled, gradually reduce dosage to the lowest effective level.
Discontinue intranasal flunisolide in patients who do not experience clinically important benefit within 3 weeks of initiating therapy.
Pediatric Patients
Seasonal Rhinitis Intranasal InhalationChildren 6–14 years of age: 1 spray (25 mcg) in each nostril 3 times daily or 2 sprays (50 mcg) in each nostril twice daily (total dose: 150–200 mcg/day).
Perennial Rhinitis Intranasal InhalationChildren 6–14 years of age: 1 spray (25 mcg) in each nostril 3 times daily or 2 sprays (50 mcg) in each nostril twice daily (total dose 150–200 mcg/day).
Adults
Seasonal Rhinitis Intranasal InhalationUsual initial dose is 50 mcg (2 sprays) in each nostril twice daily. When necessary, increase to 50 mcg (2 sprays) in each nostril 3 times daily.
Maintenance: 25 mcg (1 spray) in each nostril daily (50 mcg total) may be sufficient.
Perennial Rhinitis Intranasal InhalationUsual initial dose is 50 mcg (2 sprays) in each nostril twice daily. When necessary, increase to 50 mcg (2 sprays) in each nostril 3 times daily.
Maintenance: 25 mcg (1 spray) in each nostril daily (50 mcg total) may be sufficient.
Prescribing Limits
No evidence that higher than recommended dosages or increased frequency of administration is beneficial.
Exceeding the maximum recommended daily dosage may only increase the risk of adverse systemic effects (e.g., HPA-axis suppression, Cushing’s syndrome).
Pediatric Patients
Seasonal Rhinitis Intranasal InhalationChildren 6-14 years of age: daily dosage should not exceed 100 mcg (4 sprays) in each nostril (200 mcg total).
Perennial Rhinitis Intranasal InhalationChildren 6-14 years of age: daily dosage should not exceed 100 mcg (4 sprays) in each nostril (200 mcg total).
Adults
Seasonal Rhinitis Intranasal InhalationDaily dosage should not exceed 200 mcg (8 sprays) in each nostril (400 mcg total).
Perennial Rhinitis Intranasal InhalationDaily dosage should not exceed 200 mcg (8 sprays) in each nostril (400 mcg total).
Special Populations
Hepatic Impairment
No specific dosage recommendations for hepatic impairment.
Renal Impairment
No specific dosage recommendations for renal impairment.
Geriatric Patients
No specific geriatric dosage recommendations.
Warnings
Contraindications
Warnings/Precautions
Warnings
Withdrawal of Systemic Corticosteroid TherapyPatients being switched from prolonged systemic corticosteroids to intranasal therapy should be monitored carefully since corticosteroid withdrawal symptoms (e.g., joint pain, muscular pain, lassitude, depression), acute adrenal insufficiency, and/or severe symptomatic exacerbation of asthma or other clinical conditions may occur.
Systemic corticosteroid dosage should be tapered, and patients should be carefully monitored during dosage reduction.
Infection, Trauma, or SurgeryUse cautiously, if at all, in patients with clinical tuberculosis or asymptomatic Mycobacterium tuberculosis infections; untreated fungal, bacterial, or systemic viral or ocular herpes simplex infections; or septal ulcers, trauma, or surgery in the nasal region.
Hypothalamic-Pituitary-Adrenal (HPA) Axis SuppressionAvoid higher than recommended dosages since suppression of HPA function may occur.
ImmunosuppressionAlthough risk with intranasal use is unknown, consider the possibility that corticosteroid-induced immunosuppression could occur. Avoid exposure to varicella and measles in previously unexposed patients.
General Precautions
Systemic Corticosteroid EffectsExcessive intranasal dosages or use in patients who are particularly sensitive to corticosteroid effects may cause systemic corticosteroid effects (e.g., Cushing’s syndrome, adrenal suppression).
Nasopharyngeal EffectsTemporary or permanent loss of smell may occur.
Rarely, localized candidal infections of the nose and/or pharynx. Treat suspected local infection appropriately ; may require discontinuance of flunisolide therapy.
Rarely, nasal septal perforations.
Avoid use until healing occurs in patients with recurrent epistaxis, recent nasal septal ulcers, nasal surgery, or nasal trauma.
Oral EffectsTemporary or permanent loss of taste may occur.
Specific Populations
PregnancyCategory C.
LactationOther corticosteroids known to be distributed into milk. Caution if used in nursing women.
May cause adverse effects (e.g., growth suppression) in nursing infants if distributed.
Pediatric UseMay be a useful therapeutic alternative to oral corticosteroids in children ≥6 years of age with seasonal or perennial allergic rhinitis, since intranasal administration is associated with a decreased risk of adverse systemic effects.
Intranasal corticosteroids may reduce growth velocity in pediatric patients.
Safety and efficacy haven’t been established in children < 6 months of age.
Common Adverse Effects
Mild, transient nasal burning and stinging, aftertaste, nasal congestion, epistaxis, headache, watery eyes, nausea, vomiting, abdominal bloating, upper respiratory tract infection, cold symptoms.
What other drugs will affect Flunisolide (EENT)
No reports to date of clinically important drug interactions.
Drugs Affecting Hepatic Microsomal Enzymes
Phenobarbital and other agents that induce hepatic microsomal enzymes may enhance the metabolism of corticosteroids.
Disclaimer
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