Flurbiprofen (EENT)
Brand names: Ocufen
Drug class:
Antineoplastic Agents , Antineoplastic Agents , Antineoplastic Agents , Antineoplastic Agents
Usage of Flurbiprofen (EENT)
Inhibition of Intraoperative Miosis
Prophylactically before ocular surgery (e.g., cataract extraction) to prevent or reduce intraoperative miosis.
Postoperative Ocular Inflammation
Has been used for prevention and management of postoperative ocular inflammation† [off-label] associated with argon laser trabeculoplasty and cyclocryotherapy.
Cystoid Macular Edema
Has been used for prevention of postoperative cystoid macular edema† [off-label] associated with cataract extraction.
Inhibition of Corneal Neovascularization
Has been reported to inhibit corneal neovascularization† [off-label] induced by chemical or thermal burns or prolonged use of contact lenses in preliminary research in animals.
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How to use Flurbiprofen (EENT)
Administration
Ophthalmic Administration
Apply topically to the eye as an ophthalmic solution.
Avoid contamination of the solution container.
Dosage
Available as flurbiprofen sodium; dosage expressed in terms of flurbiprofen sodium.
Adults
Inhibition of Intraoperative Miosis Ophthalmic1 drop of 0.03% solution into the eye(s) undergoing surgery beginning 2 hours before the surgery; repeat at approximately 30-minute intervals for a total of 4 drops per affected eye.
Warnings
Contraindications
Known hypersensitivity to flurbiprofen sodium or any ingredient in the formulation.
Warnings/Precautions
Warnings
Hematologic EffectsMay inhibit platelet aggregation and prolong bleeding time.
May cause increased bleeding of ocular tissues (including hyphemas) when used in conjunction with ocular surgery.
Use with caution in patients with underlying bleeding tendencies or in those receiving drugs known to prolong bleeding time. (See Specific Drugs under Interactions.)
Sensitivity Reactions
Hypersensitivity ReactionsPossible cross-sensitivity with aspirin and other NSAIAs. Use with caution in patients with history of hypersensitivity to these drugs (severe, nearly fatal anaphylactic reaction to oral flurbiprofen reported) and in whom asthma, rhinitis, or urticaria is precipitated by aspirin or other NSAIAs.
General Precautions
Wound-healing ComplicationsMay slow or delay wound healing (including corneal).
Ocular EffectsExacerbation of active epithelial herpes simplex keratitis (dendritic keratitis), more severe conjunctivitis, corneal perforation, and/or clouding of cornea reported in animals. Use with extreme caution in patients with active epithelial herpes simplex keratitis.
Specific Populations
PregnancyCategory C.
LactationDistributed into milk after systemic administration; not known whether distributed into milk after topical application to the eye. Discontinue nursing or the drug.
Pediatric UseSafety and efficacy not established.
Geriatric UseNo substantial differences in safety and efficacy relative to younger adults.
Common Adverse Effects
Ocular stinging, burning, or discomfort and other minor symptoms of ocular irritation (e.g., tearing, dry eye sensation, dull eye pain, photophobia); itching; foreign body sensation; fibrosis; miosis; and mydriasis.
What other drugs will affect Flurbiprofen (EENT)
Interactions with other topical ophthalmic drugs not fully evaluated.
Specific Drugs
Drug
Interaction
Comments
Acetylcholine chloride
Diminished miotic effect reported when used with flurbiprofen, although recent clinical and animal studies suggest no interaction
Anesthetics, local (e.g., benoxinate, Capsaicin)
Additive effects on miotic inhibition during ocular surgery demonstrated in animals
Anticoagulants
Possible bleeding complications
Use with caution
Diminished miotic effect reported when used with flurbiprofen, although recent clinical and animal studies suggest no interaction
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