Futibatinib

Generic name: Futibatinib
Brand names: Lytgobi
Drug class: Multikinase inhibitors

Usage of Futibatinib

Futibatinib is used in adults to treat bile duct cancer that has spread (metastatic) or cannot be removed by surgery:

  • who have already received another treatment; and
  • whose tumor has an abnormal "FGFR2" gene.
  • Your doctor will make sure you have the correct tumor type to be treated with futibatinib.

    Futibatinib may also be used for purposes not listed in this medication guide.

    Futibatinib side effects

    Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

    Futibatinib may cause serious side effects. Call your doctor at once if you have:

  • changes in your vision, including blurred vision, seeing flashes of light, or black spots;
  • muscle cramps; or
  • numbness or tingling feeling around your mouth.
  • Common side effects of futibatinib may include:

  • stomach pain, nausea, vomiting, constipation, diarrhea, loss of appetite;
  • dry mouth, skin, or eye;
  • pain and burning when you urinate;
  • tiredness or weakness;
  • redness, swelling, pain, or blisters on the palms of your hands or the soles of your feet;
  • muscle or joint pain;
  • changes in your sense of taste;
  • change in appearance or color of nails;
  • hair loss;
  • abnormal lab tests;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;
  • low blood sugar--headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky;
  • low blood potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;
  • high calcium levels--confusion, tiredness, nausea, vomiting, loss of appetite, constipation, increased thirst or urination, weight loss;
  • low blood sodium--headache, confusion, problems with thinking or memory, weakness, feeling unsteady; or
  • low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Futibatinib

    Tell your doctor if you have:

  • vision or eye problems.
  • Futibatinib can harm an unborn baby if the mother or the father is using futibatinib.

  • If you are a woman, you may need a pregnancy test to make sure you are not pregnant. Use birth control while using this medicine and for at least 1 week after your last dose.
  • If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 1 week after your last dose.
  • Tell your doctor right away if a pregnancy occurs.
  • Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

    Relate drugs

    How to use Futibatinib

    Usual Adult Dose for Cholangiocarcinoma of biliary tract:

    Usual dose: 20 mg (five 4 mg tablets) taken orally once dailyComments: -Confirm the presence of an FGFR2 gene fusion or other rearrangement prior to initiation of treatment.-Treatment to be continued until disease progression or unacceptable toxicity occurs.Use: Patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma harboring fibroblast growth factor receptor 2 (FGFR2) gene fusions or other rearrangements.

    Warnings

    Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

    What other drugs will affect Futibatinib

    Tell your doctor about all your other medicines, especially:

  • itraconazole; or
  • rifampin.
  • This list is not complete. Other drugs may affect futibatinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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