Gatifloxacin (EENT)
Brand names: Zymar
Drug class:
Antineoplastic Agents
Usage of Gatifloxacin (EENT)
Bacterial Ophthalmic Infections
Topical treatment of bacterial conjunctivitis caused by susceptible Staphylococcus aureus, S. epidermidis, Streptococcus mitis group, S. oralis, S. pneumoniae, or Haemophilus influenzae.
Many cases of mild, acute bacterial conjunctivitis resolve spontaneously without anti-infective therapy. Although topical ophthalmic anti-infectives may shorten time to resolution and reduce severity and risk of complications, avoid indiscriminate use of topical anti-infectives.
Treatment of acute bacterial conjunctivitis generally is empiric; use of a broad-spectrum topical ophthalmic antibacterial usually recommended. In vitro staining and/or cultures of conjunctival material may be indicated in diagnosis and management of recurrent, severe, or chronic purulent conjunctivitis or when acute conjunctivitis does not respond to initial empiric topical treatment.
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How to use Gatifloxacin (EENT)
Administration
Ophthalmic Administration
Apply 0.5% ophthalmic solution topically to the eye.
For topical ophthalmic use only; do not inject directly into anterior chamber of the eye. (See Administration Precautions under Cautions.)
Avoid contaminating applicator tip with material from eye, fingers, or other source.
Dosage
Pediatric Patients
Bacterial Ophthalmic Infections Conjunctivitis OphthalmicChildren ≥1 year of age: Instill 1 drop of 0.5% solution in the affected eye(s) every 2 hours while awake (up to 8 times daily) on day 1, then 1 drop 2–4 times daily while awake on days 2 through 7.
Adults
Bacterial Ophthalmic Infections Conjunctivitis OphthalmicInstill 1 drop of 0.5% solution in the affected eye(s) every 2 hours while awake (up to 8 times daily) on day 1, then 1 drop 2–4 times daily while awake on days 2 through 7.
Warnings
Contraindications
Warnings/Precautions
Sensitivity Reactions
HypersensitivityHypersensitivity reactions, including anaphylactic reactions, angioedema (e.g., pharyngeal, laryngeal, or facial edema), dyspnea, urticaria, and itching, reported in patients receiving Gatifloxacin ophthalmic solution. Stevens-Johnson syndrome reported rarely.
Hypersensitivity reactions have occurred following a single dose.
Immediately discontinue at first sign of rash or hypersensitivity reaction.
Administration Precautions
For topical ophthalmic use only.
Corneal endothelial cell injury may occur if gatifloxacin ophthalmic solution is introduced directly into anterior chamber of the eye.
Superinfection
Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi.
If superinfection occurs, discontinue gatifloxacin ophthalmic solution and institute appropriate therapy.
Patient Monitoring
Whenever clinical judgment dictates, examine patient with the aid of magnification (e.g., slit lamp biomicroscopy) and, if appropriate, fluorescein staining.
Contact Lenses
Do not wear contact lenses during treatment with gatifloxacin ophthalmic solution or if any signs or symptoms of bacterial conjunctivitis are present.
Specific Populations
PregnancyData not available regarding use of gatifloxacin 0.5% ophthalmic solution in pregnant women.
LactationDistributed into milk in rats after oral administration; not known whether distributed into human milk following topical application to the eye.
Consider benefits of breast-feeding and importance of the drug to the woman; also consider potential adverse effects on the breast-fed child from the drug or underlying maternal condition.
Pediatric UseSafety and efficacy not established in children <1 year of age.
Geriatric UseNo overall differences in safety and efficacy relative to younger adults.
Common Adverse Effects
Worsening of conjunctivitis, eye irritation, dysgeusia, eye pain.
What other drugs will affect Gatifloxacin (EENT)
No formal drug interaction studies using gatifloxacin 0.5% ophthalmic solution.
Disclaimer
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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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