Gemfibrozil

Generic name: Gemfibrozil
Brand names: Lopid
Dosage form: oral tablet (600 mg)
Drug class: Fibric acid derivatives

Usage of Gemfibrozil

Gemfibrozil helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries).

Gemfibrozil is used together with diet to treat very high cholesterol and triglyceride levels in people with pancreatitis.

Gemfibrozil is also used to lower the risk of stroke, heart attack, or other heart complications in certain people with high cholesterol and triglycerides who have not been helped by other treatment methods.

Gemfibrozil side effects

Get emergency medical help if you have signs of an allergic reaction to gemfibrozil: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, gemfibrozil can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Also call your doctor at once if you have:

sharp pain in your upper stomach (especially after eating);

jaundice (yellowing of your skin or eyes);

pain or burning when you urinate;

blurred vision, eye pain, or seeing halos around lights; or

low blood cell counts - pale skin, easy bruising, unusual bleeding, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

Common gemfibrozil side effects may include:

stomach pain, indigestion, diarrhea;

numbness or tingly feeling;

dizziness, drowsiness;

blurred vision;

muscle or joint pain; or

loss of interest in sex, impotence.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Gemfibrozil

You should not use gemfibrozil if you are allergic to it, if you have:

severe liver disease;

severe kidney disease;

gallbladder disease; or

if you are also taking repaglinide, dasabuvir, or simvastatin.

To make sure gemfibrozil is safe for you, tell your doctor if you have ever had::

gallstones; or

if you also take warfarin (Coumadin, Jantoven).

It is not known whether gemfibrozil will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Relate drugs

How to use Gemfibrozil

Usual Adult Dose of Gemfibrozil for Hyperlipidemia:

600 mg orally twice a day, 30 minutes before the morning and evening meals Uses: As an adjunct to diet in the following situations: to treat hypertriglyceridemia in Types IV and V hyperlipidemia in patients who present at risk for pancreatitis and who do not respond adequately to diet; to reduce the risk for coronary heart disease (CHD) only in Type IIb patients without a history of or symptoms of existing CHD who have not responded adequately to other pharmacologic agents and nonpharmacologic interventions and who have low high density lipoprotein (HDL), elevated low density lipoprotein (LDL), and elevated triglycerides

Usual Adult Dose of Gemfibrozil for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL):

Usual Adult Dose of Gemfibrozil for Hyperlipoproteinemia Type IV (Elevated VLDL):

Usual Adult Dose for Hyperlipoproteinemia Type V (Elevated Chylomicrons + VLDL):

Usual Adult Dose for Hypertriglyceridemia:

Usual Adult Dose for Prevention of Cardiovascular Disease:

Warnings

You should not take gemfibrozil if you have severe liver or kidney disease, gallbladder disease, or if you are also taking repaglinide, dasabuvir, or simvastatin.

What other drugs will affect Gemfibrozil

Using certain medicines together with gemfibrozil can increase your risk of serious muscle problems. It is very important to tell your doctor about all medicines you use, and those you start or stop using, especially:

colchicine; or

a "statin" cholesterol-lowering medicine - atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, simvastatin, Crestor, Lipitor, Zocor, Vytorin, and others.

This list is not complete and many other drugs may interact with gemfibrozil. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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