Gentamicin (EENT)
Brand names: Gentak
Drug class:
Antineoplastic Agents
Usage of Gentamicin (EENT)
Bacterial Ophthalmic Infections
Topical treatment of superficial bacterial infections of the eye caused by susceptible bacteria, including Staphylococcus aureus, S. epidermidis, Streptococcus pyogenes, S. pneumoniae, Enterobacter aerogenes, EscheriChia coli, Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Serratia marcescens, and Pseudomonas aeruginosa.
Mild, acute bacterial conjunctivitis often resolves spontaneously without anti-infective treatment. Although topical ophthalmic anti-infectives may shorten time to resolution and reduce severity and risk of complications, avoid indiscriminate use of topical anti-infectives. Treatment of acute bacterial conjunctivitis generally is empiric; use of a broad-spectrum topical ophthalmic antibacterial usually recommended. In vitro staining and/or cultures of conjunctival material may be indicated in management of recurrent, severe, or chronic purulent conjunctivitis or when acute conjunctivitis does not respond to initial empiric topical treatment.
Because bacterial keratitis may be associated with subsequent loss of vision as the result of corneal scarring or topographic irregularities and because untreated or severe bacterial keratitis may result in corneal perforation with potential for endophthalmitis and possible loss of the eye, optimal management involves rapid evaluation and diagnosis, timely initiation of treatment, and appropriate follow-up. Treatment of community-acquired bacterial keratitis generally is empiric; use of a broad-spectrum topical ophthalmic antibacterial usually recommended. SuBConjunctival anti-infectives may be necessary if scleral spread or perforation is imminent. In vitro staining and/or cultures of corneal material indicated in management of keratitis involving corneal infiltrates that are central, large, and extend to the middle to deep stroma; when keratitis is chronic or unresponsive to a broad-spectrum topical anti-infective; or when atypical features suggest fungal, amebic, or mycobacterial infection.
Ocular Inflammation
Fixed-combination ophthalmic preparations containing gentamicin and a corticosteroid (i.e., prednisolone): Topical treatment of corticosteroid-responsive ocular conditions when a corticosteroid indicated and superficial bacterial ocular infection or risk of such infection exists.
Although manufacturers state that use of a fixed-combination ophthalmic preparation containing an anti-infective and a corticosteroid may be indicated in ocular inflammatory conditions when risk of superficial ocular infection is high or when potentially dangerous numbers of bacteria are expected to be present in the eye, experts state avoid use of such preparations in patients with bacterial conjunctivitis because of risk of potentiating the infection.
Consider that use of fixed-combination ophthalmic preparations containing an anti-infective and a corticosteroid may mask clinical signs of bacterial, fungal, or viral infections; prevent recognition of ineffectiveness of the anti-infective; and/or increase IOP. (See Use of Fixed combinations Containing Corticosteroids under Cautions.)
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How to use Gentamicin (EENT)
Administration
Ophthalmic Administration
Apply Gentamicin ophthalmic ointment or solution topically to the eye.
Apply fixed-combination ophthalmic ointment or suspension containing gentamicin and a corticosteroid (i.e., prednisolone) topically to the eye.
For topical ophthalmic use only; do not inject subconjunctivally or directly into anterior chamber of the eye.
Avoid contaminating container tip with material from eye, eyelid, or any other source.
Shake fixed-combination ophthalmic suspension well prior to use.
Dosage
Available as gentamicin sulfate alone or in fixed combination with prednisolone acetate. Dosage of gentamicin expressed in terms of the base; dosage of prednisolone acetate expressed in terms of the salt.
Pediatric Patients
Bacterial Ophthalmic Infections OphthalmicGentamicin 0.3% (ophthalmic ointment) in pediatric patients ≥1 month of age: Apply approximately 1.25-cm (½-inch) ribbon in affected eye(s) 2 or 3 times daily.
Gentamicin 0.3% (ophthalmic solution) in pediatric patients ≥1 month of age: Instill 1 or 2 drops into affected eye(s) every 4 hours. For severe infections, up to 2 drops may be instilled every hour.
Usual duration of topical anti-infective treatment for bacterial conjunctivitis is 5–10 days; 5–7 days usually adequate for mild bacterial conjunctivitis.
Adults
Bacterial Ophthalmic Infections OphthalmicGentamicin 0.3% (ophthalmic ointment): Apply approximately 1.25-cm (½-inch) ribbon in affected eye(s) 2 or 3 times daily.
Gentamicin 0.3% (ophthalmic solution): Instill 1 or 2 drops into affected eye(s) every 4 hours. For severe infections, up to 2 drops may be instilled every hour.
Usual duration of topical anti-infective treatment for bacterial conjunctivitis is 5–10 days; 5–7 days usually adequate for mild bacterial conjunctivitis.
Ocular Inflammation OphthalmicGentamicin 0.3% and prednisolone acetate 0.6% (ophthalmic ointment): Apply approximately 1.25-cm (½-inch) ribbon into conjunctival sac of affected eye(s) 1–3 times daily.
Gentamicin 0.3% and prednisolone acetate 1% (ophthalmic suspension): Instill 1 drop into conjunctival sac of affected eye(s) 2–4 times daily. During initial 24–48 hours, 1 drop may be instilled every hour if necessary.
If no improvement after 2 days, reevaluate patient. Do not discontinue prematurely.
Warnings
Contraindications
Warnings/Precautions
Sensitivity Reactions
HypersensitivityAllergic reactions reported.
If hypersensitivity occurs, immediately discontinue and initiate appropriate therapy.
Superinfection
Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi.
Bacterial resistance to gentamicin may occur.
Bacterial and fungal corneal ulcers have developed.
Precautions Related to Ophthalmic Administration
Manufacturer cautions that ophthalmic ointments may delay corneal healing.
Use of Fixed Combinations Containing Corticosteroids
When ophthalmic preparations containing gentamicin in fixed combination with a corticosteroid (i.e., prednisolone) used, consider cautions, precautions, and contraindications associated with EENT corticosteroids.
Provide initial prescriptions for fixed-combination ophthalmic preparations containing a corticosteroid or renewal prescriptions (beyond 8 g of ophthalmic ointment or beyond 20 mL of ophthalmic solution) only after measuring IOP and examining patient with slit lamp microscopy and, when appropriate, fluorescein staining.
Prolonged use of fixed-combination ophthalmic preparations containing a corticosteroid may result in glaucoma, with optic nerve damage, defects in visual acuity and fields of vision, and posterior subcapsular cataract formation. If such preparation used for ≥10 days, routinely monitor IOP, even though this may be difficult in children and uncooperative patients. Use fixed combinations containing a corticosteroid with caution in patients with glaucoma; check IOP frequently in such patients.
Use of fixed-combination ophthalmic preparations containing a corticosteroid after cataract surgery may delay healing and increase incidence of bleb formation.
Corneal and scleral thinning reported with various ocular diseases and with long-term use of topical corticosteroids. Use of topical corticosteroids in patients with thin corneal and scleral tissue may result in perforation.
Prolonged use of fixed-combination ophthalmic preparations containing a corticosteroid may suppress host responses and increase risk of secondary ocular infections. Use in patients with acute purulent conditions of the eye may mask infection or enhance existing infection.
May prolong course and exacerbate severity of many viral infections of the eye (including herpes simplex). Use with great caution in patients with herpes simplex; frequent slit lamp microscopy recommended.
Consider possibility of fungal infections of the cornea after prolonged use of ophthalmic preparations containing a corticosteroid. Perform fungal cultures when appropriate.
Specific Populations
PregnancyNo adequate and well-controlled studies using ophthalmic preparations containing gentamicin in pregnant women.
Use gentamicin ophthalmic preparations, including fixed-combination preparations containing gentamicin and a corticosteroid, during pregnancy only if potential benefits justify potential risks to fetus.
LactationSystemic gentamicin is distributed into milk.
Discontinue nursing or the drug, taking into account importance of the drug to the woman.
Pediatric UseGentamicin ophthalmic ointment or solution: Safety and efficacy not established in neonates.
Fixed-combination ophthalmic preparations containing gentamicin and a corticosteroid (i.e., prednisolone): Safety and efficacy not established in pediatric patients.
Geriatric UseFixed-combination ophthalmic preparations containing gentamicin and prednisolone: No overall differences in safety or efficacy relative to younger adults.
Common Adverse Effects
Ocular burning and irritation, nonspecific conjunctivitis, conjunctival epithelial defects, conjunctival hyperemia.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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