Gentamicin (Injection)

Generic name: Gentamicin
Drug class: Aminoglycosides

Usage of Gentamicin (Injection)

Gentamicin injection is used to treat serious bacterial infections in many different parts of the body.

Gentamicin belongs to the class of medicines known as aminoglycoside antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

Gentamicin injection is usually used for serious bacterial infections for which other medicines may not work. However, it may also cause some serious side effects, including damage to your kidneys and the part of your body that controls hearing. These side effects may be more likely to occur in elderly patients and newborn infants. You and your doctor should talk about the benefit of this medicine as well as the risks.

This medicine is to be administered only by or under the immediate supervision of your doctor.

Gentamicin (Injection) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

Abdominal or stomach cramps or pain

agitation

back pain

black, tarry stools

blood in the urine

blurred or double vision

burning, numbness, tingling, or painful sensations

change in frequency of urination or amount of urine

chest pain

chills

coma

confusion

continuing ringing or buzzing or other unexplained noise in the ears

cough

difficult or troubled breathing

difficulty with swallowing

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness

dry mouth

eye pain

fast heartbeat

fever with or without chills

hallucinations

headache

hearing loss

hives

hoarseness

increased thirst

irregular heartbeats

irregular, fast or slow, or shallow breathing

irritability

itching

joint pain

loss of appetite

mood or mental changes

muscle cramps in the hands, arms, feet, legs, or face

muscle pain or weakness

muscle spasms (tetany) or twitching

nausea or vomiting

nervousness

numbness and tingling around the mouth, fingertips, or feet

pale or blue lips, fingernails, or skin

pale skin

pinpoint red spots on the skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

right upper abdominal or stomach pain and fullness

seizures

sensation of spinning

skin rash

slow or fast heartbeat

slow or irregular breathing

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stiff neck

sweating

swelling of the feet or lower legs

swollen glands

tightness in the chest

trembling

unusual bleeding or bruising

unusual tiredness or weakness

weight chest discomfort

weight loss

wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

Blurred or loss of vision

decreased appetite

depression

disturbed color perception

hair loss or thinning of the hair

halos around lights

hives or welts

increased salivation

night blindness

overbright appearance of lights

pain at the injection site

purple spots on the skin

redness of the skin

swelling or inflammation of the mouth

tunnel vision

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Gentamicin (Injection)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of gentamicin injection in children. However, this medicine should be used with caution in premature and newborn infants.

Geriatric

No information is available on the relationship of age to the effects of gentamicin injection in geriatric patients. However, elderly patients are more likely to have kidney problems, which may require caution and an adjustment in the dose for patients receiving gentamicin injection.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Ataluren

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Agalsidase Alfa

Alcuronium

Aspirin

Atracurium

Cholera Vaccine, Live

Cidofovir

Cisatracurium

Colistimethate Sodium

Decamethonium

Digoxin

Doxacurium

Emtricitabine

Ethacrynic Acid

Fazadinium

Foscarnet

Furosemide

Gallamine

Hexafluorenium

Lysine

Metocurine

Mivacurium

Pancuronium

Pipecuronium

Rapacuronium

Rocuronium

Succinylcholine

Tacrolimus

Tenofovir Alafenamide

Tubocurarine

Vancomycin

Vecuronium

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Indomethacin

Methoxyflurane

Polygeline

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Relate drugs

How to use Gentamicin (Injection)

A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into a muscle or into a vein.

To help clear up your infection completely, keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. Also, this medicine works best when there is a constant amount in the blood. To help keep the amount constant, you must receive this medicine on a regular schedule.

To keep your kidneys working well and help prevent kidney problems, drink extra fluids so you will pass more urine while you or your child are receiving this medicine.

Warnings

Your doctor will check your progress closely while you or your child are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you or your child should continue to receive it. Blood, urine, hearing, and nerve tests may be needed to check for unwanted effects.

If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you or your child have itching; hives; hoarseness; shortness of breath; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive this medicine.

Stop using this medicine and check with your doctor right away if you or your child have sudden decrease in hearing or loss of hearing, which may be accompanied by dizziness and ringing in the ears. Tell your doctor if you or your child have dizziness or lightheadedness; feeling of constant movement of self or surroundings; or sensation of spinning. These may be symptoms of a damage to your hearing or sense of balance.

Check with your doctor right away if you or your child have blood in the urine, change in frequency of urination or amount of urine, difficulty with breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of feet or lower legs, or weakness. These may be symptoms of a serious kidney problem (e.g., Fanconi-like syndrome).

This medicine may cause nerve problems. Check with your doctor right away if you or your child have numbness, skin tingling, muscle twitching, or convulsions.

Make sure your doctor knows that you are using this medicine before having a surgery or other procedures that require you to receive a numbing medicine (e.g., anesthetics, neuromuscular blocking agents). Using gentamicin injection together with numbing medicines may increase your risk of having difficulty in breathing, drowsiness, inability to breath without assistance, or unusual tiredness or weakness.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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