Generic name: Metoclopramide (nasal Spray) Drug class:GI stimulants
Usage of Gimoti
Gimoti is a prescription medicine used in adults to relieve the symptoms of slow stomach emptying in people with diabetes.
Gimoti is not recommended for use in people who:
have kidney or liver problems.
have been told that an enzyme in their body, called CYP2D6, breaks down (metabolizes) certain medicines in the body too slowly.
are also taking medicine called CYP2D6 inhibitors, which slows how fast the body breaks down (metabolizes) certain medicines.
Gimoti is not recommended for use in children.
It is not known if this medicine is safe and effective in children.
Gimoti side effects
Gimoti can cause serious side effects, including:
Tardive dyskinesia (abnormal muscle movements). See Important information.
Other changes in muscle control and movement, such as:
Uncontrolled spasms of your face and neck muscles, or muscles of your body, arms, and legs (dystonia). These muscle spasms can cause abnormal movements and body positions and speech problems. These spasms usually start within the first 2 days of treatment. Rarely, these muscle spasms may cause trouble breathing. These spasms happen more often in adults less than 30 years of age.
Parkinsonism. Symptoms include slight shaking, body stiffness, and trouble moving or keeping your balance. If you already have Parkinson's Disease, your symptoms may become worse while you are taking Gimoti.
Being unable to sit still or feeling you need to move your hands, feet, or body (akathisia). Symptoms can include feeling jittery, anxious, irritated, or unable to sleep (insomnia), feeling the need to walk around (pacing), and tapping your feet. Your healthcare provider may stop your treatment if you develop these symptoms.
Neuroleptic Malignant Syndrome (NMS). NMS is a very rare, but very serious condition that can happen with Gimoti. NMS can cause death and must be treated in a hospital. Symptoms of NMS include: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, and increased sweating.
Depression, thoughts about suicide, and suicide. Some people who take Gimoti may become depressed, even if they have no history of depression. You may have thoughts about hurting or killing yourself. Some people who have taken metoclopramide have ended their own lives (suicide).
High blood pressure. Gimoti can cause your blood pressure to increase. Your healthcare provider may stop treatment if your blood pressure to increase very fast.
Too much body water. People who have certain liver problems or heart failure and take Gimoti may hold too much water in their body (fluid retention). Tell your healthcare provider right away if you have sudden weight gain, or swelling of your hands, legs, or feet.
Increased prolactin. Tell your healthcare provider if your menstrual periods stop or your breasts get larger and make milk. These symptoms go away when you stop taking Gimoti.
Call your healthcare provider and get medical help right away if you:
feel depressed or have thoughts about hurting or killing yourself
have high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, and increased sweating
have muscle movements you cannot stop or control
have muscle movements that are new or unusual
The most common side effects include:
unpleasant taste
headache
tiredness
You may have more side effects the longer you take Gimoti and the more Gimoti you take.
You may still have side effects after stopping Gimoti. You may have symptoms from stopping Gimoti such as headaches and feeling dizzy or nervous.
Tell your healthcare provider about any side effect that bothers you or that does not go away. These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Gimoti
Do not take Gimoti if you:
have a history of tardive dyskinesia or have a problem controlling your muscles and movements after taking Gimoti or a medicine that works like Gimoti.
have stomach or intestine problems that could get worse with Gimoti, such as bleeding, blockage, or a tear in the stomach or bowel wall.
have a type of tumor that can cause high blood pressure, such as pheochromocytoma.
have epilepsy (seizures). Gimoti can increase your chance for seizures and make them worse.
are allergic to metoclopramide. Gimoti can cause serious allergic reactions. Stop taking Gimoti right away and get emergency help if you have any of these symptoms:
swelling of your tongue, throat, lips, eyes, or face
trouble swallowing or breathing
skin rash, hives, sores in your mouth, or skin blisters
Read the step-by-step Instructions for Use that come with your prescription.
Take Gimoti exactly as your healthcare provider tells you. Do not change your dose unless your healthcare provider tells you to.
Gimoti comes as a liquid in a glass bottle with a spray pump attached.
You should not take Gimoti for more than 8 weeks at a time.
You should not take medicines containing metoclopramide (including Gimoti) for more than 12 weeks at a time.
Take Gimoti at least 30 minutes before each meal and at bedtime.
If you are not certain that the spray entered the nose, skip the dose and take your next dose at your regular schedule time. Do not take an extra dose at the schedule time. If you miss a dose, skip that dose and take your next dose at your regular scheduled time. Do not take an extra dose to make up for a missed dose.
If you take too much Gimoti, call your poison control center at 1-800-222-1222 or go to the nearest emergency room right away.
Warnings
Gimoti can cause serious side effects, including: Tardive dyskinesia (abnormal muscle movements). These movements happen mostly in the face muscles. You cannot control these movements. They may not go away even after stopping Gimoti. Your chances for getting tardive dyskinesia increase:
the longer you take Gimoti and the more Gimoti you take. You should not take Gimoti for more than 8 weeks at a time, and you should not take products containing metoclopramide (including Gimoti) for more than 12 weeks at a time.
if you are older, especially if you are an older woman.
because you have diabetes.
It is not possible for your healthcare provider to know if you will get tardive dyskinesia if you take Gimoti. Call your healthcare provider right away if you get movements you cannot stop or control, such as:
lip smacking, chewing, or puckering up your mouth
frowning or scowling
sticking out your tongue
blinking and moving your eyes
shaking of your arms and legs
Your healthcare provider may stop treatment if you develop signs or symptoms of tardive dyskinesia. See the section Gimoti side effects for more information about side effects.
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