Glasdegib

Generic name: Glasdegib
Brand names: Daurismo
Dosage form: oral tablet (100 mg; 25 mg)
Drug class: Hedgehog pathway inhibitors

Usage of Glasdegib

Glasdegib is used in adults in combination with cytarabine to treat acute myeloid leukemia. This combination is for use in adults who are 75 years or older, or who cannot receive chemotherapy due to other medical conditions.

Glasdegib may also be used for purposes not listed in this medication guide.

Glasdegib side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Glasdegib may cause serious side effects. Call your doctor at once if you have:

irregular or fast heartbeats, shortness of breath, and sudden dizziness (like you might pass out);

easy bruising, unusual bleeding, purple or red spots under your skin;

any new or worsening muscle pain or muscle spasms; or

low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of glasdegib may include:

bleeding;

fever, low blood cell counts;

changes in your sense of taste;

pain or sores in mouth or throat;

loss of appetite, constipation, nausea;

rash;

muscle pain;

swelling in your arms or legs;

feeling tired; or

trouble breathing.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Glasdegib

Tell your doctor if you have ever had:

heart problems;

long QT syndrome (in you or a family member);

an electrolyte imbalance (such as low blood levels of potassium or magnesium);

muscle pain or muscle spasms;

kidney disease; or

liver disease.

You will need to take a pregnancy test within 7 days of starting treatment with glasdegib.

May harm an unborn baby. You will need a pregnancy test to make sure you are not pregnant. Use effective birth control while using glasdegib and for at least 30 days after your last dose. Tell your doctor if you become pregnant.

Do not breastfeed while using this medicine, and for at least 30 days after your last dose.

Men using glasdegib should use condoms during treatment, even after a vasectomy and for at least 30 days after treatment ends.

It may be harder for you to get a woman pregnant while you are using this medicine.

Relate drugs

How to use Glasdegib

Usual Adult Dose for Acute Myeloid Leukemia:

100 mg orally once a day on days 1 to 28 in combination with cytarabine 20 mg suBCutaneously 2 times a day on days 1 to 10 of each 28-day cycle in the absence of unacceptable toxicity or loss of disease control; for patients without unacceptable toxicity, treat for a minimum of 6 cycles to allow time for clinical responseUse: This drug, in combination with low-dose cytarabine, for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adult patients who are 75 years old or older or who have comorbidities that preclude use of intensive induction chemotherapy

Usual Geriatric Dose for Acute Myeloid Leukemia:

75 years or older:100 mg orally once a day on days 1 to 28 in combination with cytarabine 20 mg subcutaneously 2 times a day on days 1 to 10 of each 28-day cycle in the absence of unacceptable toxicity or loss of disease control; for patients without unacceptable toxicity, treat for a minimum of 6 cycles to allow time for clinical responseUse: This drug, in combination with low-dose cytarabine, for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adult patients who are 75 years old or older or who have comorbidities that preclude use of intensive induction chemotherapy

Warnings

Do not use if you are pregnant. Use effective birth control. Both men and women using glasdegib should use effective birth control to prevent pregnancy. Glasdegib can harm an unborn baby if the mother or father is using this medicine.

What other drugs will affect Glasdegib

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Glasdegib can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Other drugs may affect glasdegib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Disclaimer

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