Glecaprevir and pibrentasvir

Generic name: Glecaprevir And Pibrentasvir
Brand names: Mavyret
Drug class: Antiviral combinations

Usage of Glecaprevir and pibrentasvir

Glecaprevir and pibrentasvir is a combination antiviral medicine used to treat chronic hepatitis C in people with HCV genotype 1, 2, 3, 4, 5, or 6.

Glecaprevir and pibrentasvir is usually given after other treatments have failed.

Glecaprevir and pibrentasvir may also be used for purposes not listed in this medication guide.

Glecaprevir and pibrentasvir side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, glecaprevir and pibrentasvir may cause serious liver injury. Tell your doctor right away if you have symptoms such as:

right-sided upper stomach pain;

nausea, vomiting, loss of appetite;

confusion, tiredness, feeling light-headed;

easy bruising or bleeding, vomiting blood;

diarrhea, black or bloody stools;

dark urine; or

yellowing of your skin or eyes.

Common side effects of glecaprevir and pibrentasvir may include:

headache; or

tiredness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Glecaprevir and pibrentasvir

You should not use this medicine if you are allergic to glecaprevir or pibrentasvir, or if:

you have liver disease; or

you also take atazanavir or rifampin.

Tell your doctor if you have ever had:

hepatitis B;

liver problems other than hepatitis;

a liver or kidney transplant;

HIV (human immunodeficiency virus); or

an opioid addiction or past use of injected drugs.

Tell your doctor if you are pregnant or breastfeeding.

Glecaprevir and pibrentasvir should not be given to a child younger than 3 years old.

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How to use Glecaprevir and pibrentasvir

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using glecaprevir and pibrentasvir.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You should not stop using glecaprevir and pibrentasvir suddenly. Stopping suddenly could make your condition harder to treat with hepatitis C antiviral medicine.

Use all hepatitis C medications as directed and read all medication guides you receive. Do not change your dose or stop using a medicine without your doctor's advice. Every person with hepatitis C should remain under the care of a doctor.

If you've ever had hepatitis B, this virus may become active or get worse in the months after you stop using glecaprevir and pibrentasvir. You may need frequent liver function tests while using glecaprevir and pibrentasvir and for several months after your last dose.

Store this medicine in the original container at room temperature away from moisture and heat.

Warnings

You should not use glecaprevir and pibrentasvir if you have severe liver disease, or if you also take atazanavir or rifampin.

If you've ever had hepatitis B, it may become active or get worse after you stop using glecaprevir and pibrentasvir. You may need frequent liver function tests for several months.

What other drugs will affect Glecaprevir and pibrentasvir

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Other drugs can affect glecaprevir and pibrentasvir, and some drugs should not be used at the same time. Tell your doctor about all other medicines you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.