Gleostine

Generic name: Lomustine
Drug class: Alkylating agents

Usage of Gleostine

Gleostine is used to treat brain tumors in people who have already received surgery or radiation.

Gleostine is also used with other cancer medicines to treat Hodgkin's disease, after other treatments have failed.

Gleostine may also be used for purposes not listed in this medication guide.

Gleostine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Gleostine may cause serious side effects. Call your doctor at once if you have:

jaundice (yellowing of the skin or eyes);

easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;

signs of infection--fever, chills, sore throat, blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or

late-onset lung damage--new or worsening cough, chest pain, shortness of breath (may develop as long as 6 months or later after you take Gleostine).

Common side effects of Gleostine may include:

nausea, vomiting;

delayed infection;

mouth sores; or

hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Gleostine

Tell your doctor if you have ever had:

bone marrow suppression;

liver disease;

kidney disease; or

lung disease or breathing problems.

Using Gleostine may increase your risk of developing other types of cancer, such as leukemia. Ask your doctor about your specific risk.

Gleostine can harm an unborn baby if the mother or the father is using this medicine.

If you are a woman, do not use Gleostine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 2 weeks after your last dose.

If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3.5 months (14 weeks) after your last dose.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Gleostine.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because Gleostine can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

Relate drugs

How to use Gleostine

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Gleostine is taken in a single dose once every 6 weeks. Follow your doctor's dosing instructions very carefully.

Because an overdose of lomustine can be fatal, you will be given only enough of Gleostine to take one dose every 6 weeks. To get the correct dose, you may need to take 2 or more capsules that are different types and colors.

Wear disposable rubber gloves when you handle a Gleostine capsule. Throw the gloves away after one use.

Do not open the Gleostine capsule. Do not use a broken pill. The medicine from a broken pill can be dangerous if it gets on your skin. If this occurs, wash with soap and water. Ask your doctor or pharmacist how to safely handle and dispose of a broken capsule.

Gleostine can weaken (suppress) your immune system. Serious and sometimes fatal infections may occur up to 6 weeks after you are treated with this medicine. You will need frequent medical tests.

Store at room temperature away from heat and moisture. Keep the bottle tightly closed until you are ready to take the medicine.

Gleostine can have long lasting effects on your body. Your blood will need to be tested for at least 6 weeks after each dose of this medicine.

Warnings

Gleostine can weaken (suppress) your immune system. Serious and sometimes fatal infections may occur up to 6 weeks after you are treated with Gleostine. Call your doctor if you have easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), or signs of infection (fever, chills, body aches).

Gleostine can have long lasting effects on your body. Your blood will need to be tested once per week for at least 6 weeks after each dose of this medicine.

What other drugs will affect Gleostine

Other drugs may affect Gleostine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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