Glimepiride and pioglitazone
Generic name: Glimepiride And Pioglitazone
Brand names: Duetact
Dosage form: oral tablet (2 mg-30 mg; 4 mg-30 mg)
Drug class:
Antidiabetic combinations
Usage of Glimepiride and pioglitazone
Glimepiride and pioglitazone is a combination of two oral diabetes medicines that help control blood sugar levels.
Glimepiride and pioglitazone is a combination medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. glimepiride and pioglitazone is not for treating type 1 diabetes.
Glimepiride and pioglitazone may also be used for purposes not listed in this medication guide.
Glimepiride and pioglitazone side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Glimepiride and pioglitazone may cause serious side effects. Call your doctor at once if you have:
Common side effects of glimepiride and pioglitazone may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Glimepiride and pioglitazone
You should not use this medicine if you are allergic to glimepiride, pioglitazone, or sulfa drugs, or if you have:
Pioglitazone may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of taking glimepiride and pioglitazone.
Tell your doctor if you have ever had:
This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.
Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking glimepiride and pioglitazone for a short time just before your due date.
Women may be more likely to have a broken bone while taking glimepiride and pioglitazone. Talk with your doctor about ways to keep your bones healthy.
Pioglitazone may cause you to ovulate and get pregnant, even if you are premenopausal or do not have regular periods. Talk with your doctor about the need for birth control.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
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How to use Glimepiride and pioglitazone
Usual Adult Dose for Diabetes Type 2:
Individualize dose based on safety, efficacy, and prior therapyInitial dose: pioglitazone 30 mg-glimepiride 2 mg or pioglitazone 30 mg-glimepiride 4 mg orally once a day -For patients inadequately controlled on glimepiride monotherapy: pioglitazone 30 mg-glimepiride 2 mg or pioglitazone 30 mg-glimepiride 4 mg orally once a day-For patients inadequately controlled on pioglitazone monotherapy: pioglitazone 30 mg-glimepiride 2 mg orally once a day -For patients receiving pioglitazone and glimepiride as individual components: Initiate with the combination product containing doses that are as close as possible to the dose of each component-For patients currently on a different sulfonylurea monotherapy or switching from combination therapy of pioglitazone plus a different sulfonylurea: pioglitazone 30 mg-glimepiride 2 mg orally once a day -For patients with systolic dysfunction, initiate with pioglitazone monotherapy and only initiate combination therapy after titration from pioglitazone 15 mg to 30 mg has been safely tolerated. Maintenance Dose: Gradually titrate dose based on adequacy of therapeutic response and tolerability for each component Comments: -Take with first meal of the day.-For patients switching from a different sulfonylurea, carefully monitor for hypoglycemia for 1 to 2 weeks due to a potential overlapping drug effect. -If hypoglycemia occurs in a patient coadministered an insulin secretagogue, the dose of the insulin secretagogue should be reduced. -If hypoglycemia occurs in a patient's coadministered insulin, the insulin dose should be decreased by 10% to 25% with further adjustments based on glycemic response. Use: As an adjunct to diet and exercise, to improve glycemic control in adult patients with type 2 diabetes mellitus who are already treated with a thiazolidinedione and sulfonylurea or who have inadequate glycemic control in a thiazolidinedione alone or a sulfonylurea alone.
Warnings
You should not use glimepiride and pioglitazone if you have severe or uncontrolled heart failure, active bladder cancer, or diabetic ketoacidosis (call your doctor for treatment).
This medicine can cause or worsen congestive heart failure. Call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain.
What other drugs will affect Glimepiride and pioglitazone
Tell your doctor if you use insulin. Taking glimepiride and pioglitazone while you are using insulin may increase your risk of serious heart problems.
Glimepiride and pioglitazone may not work as well when you use other medicines at the same time. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all medicines you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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