Guayule

Generic name: Parthenium Argentatum A. Gray.
Brand names: Guayule, Mexican Rubber

Usage of Guayule

There are no clinical studies using guayule.

Cancer

In vitro studies have shown triterpene argentatins to possess cytotoxic activity against some human cancer cell lines. In in vitro studies, argentatin B demonstrated noncompetitive inhibition at estradiol binding sites in hormone-dependent breast cancer.(Parra-Delgado 2005)

Natural rubber latex

Clinical studies have routinely shown a lack of cross-reactivity to Hevea brasiliensis latex antibodies; thus, guayule provides an alternative source of rubber products for use in individuals with Hevea latex hypersensitivity. The FDA approved marketing of guayule-based Yulex gloves in 2008.(Cornish 1999, Mooibroek 2000, Siler 1996, van Beilen 2007, Wood 2010) A study evaluating guayule latex gloves 4 years after storage found that the latex remained impermeable to 27 nm viruses (of the order of the smallest human viral pathogens).(Cornish 1999)

Other uses

Antioxidant properties have been documented for guayule leaves and twigs (discard elements during latex production) with the highest antioxidant capacity of leaves found to be during the winter harvest time.(Piluzza 2020)

Guayule side effects

The P. argentatum plant contains cinnamic acid, present in stems and leaves, that can elicit immune reactions. Cross sensitivity to the plant and its proteins is possible in people sensitized to other species of Asteraceae, such as ragweed and feverfew.Siler 1996 The processing of guayule for its rubber results in a low-protein–content product.Cornish 1999, Wood 2010

Before taking Guayule

Information regarding safety and efficacy in pregnancy and lactation is lacking.

How to use Guayule

There are no clinical applications for guayule.

Warnings

Information is lacking; 1 study demonstrated a lack of genotoxic effects via clastogenic or aneugenic mechanisms for the constituents argentatin A and B.Parra-Delgado 2005

What other drugs will affect Guayule

None well documented.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.