Gvoke

Generic name: Glucagon (injection)
Drug class: Glucose elevating agents

Usage of Gvoke

Gvoke is a hormone that increases blood sugar levels.

Gvoke is used to treat hypoglycemia (low blood sugar). Gvoke in the HypoPen auto-injector, pre-filled syringe (PFS), and the vial and syringe kit is given by suBCutaneous (under the skin) injection.

Gvoke is for use in adults and children (aged 2 years and above) with diabetes.

Gvoke side effects

Get emergency medical help if you have signs of an allergic reaction to Gvoke: hives; difficulty breathing; fast or slow heartbeat; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of the following skin changes on your face, legs, groin, or genital area:

redness;

itching;

blistering;

crusting, scaling; or

other skin sores or lesions.

Common Gvoke side effects may include:

nausea, vomiting; or

swelling where an injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Gvoke

You should not use Gvoke if you are allergic to glucagon or lactose, or if you have:

a tumor of the pancreas (insulinoma); or

a tumor of the adrenal gland (pheochromocytoma).

Gvoke should be used to treat hypoglycemia only if the person is unable to eat, or is unconscious or having a seizure.

To make sure Gvoke is safe for you, tell your doctor if:

you have any tumor of the pancreas;

you have not recently eaten on a regular basis; or

you have chronic low blood sugar.

Glucagon is not expected to harm an unborn baby, but quickly treating hypoglycemia would outweigh any risks posed by using this medicine.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.

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How to use Gvoke

Usual Adult Dose for Hypoglycemia:

Gvoke Auto-Injector, Prefilled Syringes, and Vial and Syringe Kit: 1 mg subcutaneously once.

Usual Pediatric Dose for Hypoglycemia:

Gvoke Auto-Injector, Prefilled Syringes, and Vial and Syringe Kit 2 to 12 years (weight less than 45 kg): 0.5 mg subcutaneously once 2 to 12 years (weight 45 kg or greater): 1 mg subcutaneously once 12 years or older: 1 mg subcutaneously once REPEAT DOSE: An unconscious patient will usually awaken within 15 minutes following treatment; if response is delayed, may repeat dose while waiting for emergency assistance Comments: -After patient has responded to treatment, supplemental carbohydrates should be given to restore liver glycogen and prevent recurrence of hypoglycemia. -Patients who do not respond should receive IV glucose. Uses: For the treatment of severe hypoglycemia in patients 2 years or older.

Warnings

Gvoke should be used to treat hypoglycemia only if the person cannot eat, passes out, or is having a seizure. Be sure you know how to give a this medicine before you need to use it. Hypoglycemia should be treated as quickly as possible. Having low blood sugar for too long can cause seizure, coma, or death.

You should not use Gvoke if you are allergic to glucagon or lactose, or if you have a tumor of the pancreas (insulinoma) or adrenal gland (pheochromocytoma).

What other drugs will affect Gvoke

Many other medicines can affect your blood sugar, and some medicines can increase or decrease the effects of medicines used to treat diabetes. Some drugs can also cause you to have fewer symptoms of hypoglycemia, making it harder to tell when your blood sugar is low. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all medicines you start or stop using.

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