Hydrochlorothiazide and fosinopril

Generic name: Hydrochlorothiazide And Fosinopril
Brand names: Monopril HCT
Dosage form: oral tablet (10 mg-12.5 mg; 20 mg-12.5 mg)
Drug class: ACE inhibitors with thiazides

Usage of Hydrochlorothiazide and fosinopril

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Fosinopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Fosinopril lowers blood pressure and also relieves symptoms of fluid retention.

Hydrochlorothiazide and fosinopril is a combination medicine used to treat hypertension (high blood pressure).

Hydrochlorothiazide and fosinopril may also be used for purposes not listed in this medication guide.

Hydrochlorothiazide and fosinopril side effects

Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Hydrochlorothiazide and fosinopril may cause serious side effects. Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • pale skin, easy bruising or bleeding;
  • fever, swollen gums, painful mouth sores, pain when swallowing, cold or flu symptoms;
  • high potassium--nausea, slow or unusual heart rate, weakness, loss of movement;
  • low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling;
  • low levels of sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady; or
  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

    • Common side effects of hydrochlorothiazide and fosinopril may include:

  • headache, dizziness;
  • cough; or
  • tired feeling.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Hydrochlorothiazide and fosinopril

    You should not use this medicine if you are allergic to hydrochlorothiazide or fosinopril, or if:

  • you are unable to urinate;
  • you are allergic to sulfa drugs; or
  • you are allergic to any other ACE inhibitor, such as Benazepril, Captopril, enalapril, lisinopril, quinapril, ramipril, trandolapril, and others.

    • If you have diabetes, do not use hydrochlorothiazide and fosinopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).

    You may also need to avoid taking hydrochlorothiazide and fosinopril with aliskiren if you have kidney disease.

    To make sure hydrochlorothiazide and fosinopril is safe for you, tell your doctor if you have:

  • kidney disease (or if you are on dialysis);
  • cirrhosis or other liver disease;
  • congestive heart failure;
  • gout;
  • lupus;
  • diabetes; or
  • an allergy to sulfa drugs or penicillin.

    • Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Fosinopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

    Hydrochlorothiazide and fosinopril can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

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    How to use Hydrochlorothiazide and fosinopril

    Usual Adult Dose for Hypertension:

    Fosinopril 10 to 40 mg-Hydrochlorothiazide 12.5 to 37.5 mg orally per dayComments: The effect of fosinopril 10 mg-hydrochlorothiazide 12.5 mg was similar to the effect seen with monotherapy using either fosinopril 40 mg or hydrochlorothiazide 37.5 mg.Use: Treatment of hypertension when the desired effect has not been achieved with monotherapy or as substitution for the titrated individual components.

    Warnings

    Do not use if you are pregnant. If you become pregnant, stop taking hydrochlorothiazide and fosinopril and tell your doctor right away. Fosinopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

    You should not use this medicine if you are unable to urinate, or if you are allergic to sulfa drugs or any ACE inhibitor.

    If you have diabetes, do not use hydrochlorothiazide and fosinopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo).

    What other drugs will affect Hydrochlorothiazide and fosinopril

    Other drugs may interact with hydrochlorothiazide and fosinopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

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