Hydrochlorothiazide and losartan
Generic name: Hydrochlorothiazide And Losartan
Brand names: Hyzaar
Dosage form: oral tablet (12.5 mg-100 mg; 12.5 mg-50 mg; 25 mg-100 mg)
Drug class:
Angiotensin II inhibitors with thiazides
Usage of Hydrochlorothiazide and losartan
Hydrochlorothiazide is a diuretic (water pill). Losartan is an angiotensin II receptor antagonist (sometimes called an ARB blocker).
Hydrochlorothiazide and losartan is a combination medicine used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease.
Hydrochlorothiazide and losartan may also be used for purposes not listed in this medication guide.
Hydrochlorothiazide and losartan side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Hydrochlorothiazide and losartan may cause serious side effects. Call your doctor at once if you have:
Common side effects of hydrochlorothiazide and losartan may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Hydrochlorothiazide and losartan
You should not use this medicine if you are allergic to hydrochlorothiazide or losartan, if you are unable to urinate.
If you have diabetes, do not use hydrochlorothiazide and losartan together with any medication that contains aliskiren (a blood pressure medicine).
You may also need to avoid taking hydrochlorothiazide and losartan with aliskiren if you have kidney disease.
Tell your doctor if you have ever had:
Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant. Hydrochlorothiazide and losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
You should not breastfeed while using this medicine.
Hydrochlorothiazide and losartan is not approved for use by anyone younger than 18 years old.
Relate drugs
- Atacand HCT
- Avalide
- Azilsartan and chlorthalidone
- Benicar HCT
- Candesartan and hydrochlorothiazide
- Diovan HCT
- Edarbyclor
- Eprosartan and hydrochlorothiazide
- Hydrochlorothiazide and candesartan
- Hydrochlorothiazide and irbesartan
- Hydrochlorothiazide and losartan
- Hydrochlorothiazide and olmesartan
- Hydrochlorothiazide and telmisartan
- Hydrochlorothiazide and valsartan
- Hyzaar
- Irbesartan and hydrochlorothiazide
- Losartan and hydrochlorothiazide
- Micardis HCT
- Olmesartan and hydrochlorothiazide
- Telmisartan and hydrochlorothiazide
- Teveten HCT
- Valsartan and hydrochlorothiazide
How to use Hydrochlorothiazide and losartan
Usual Adult Dose for Hypertension:
HYPERTENSION:Hydrochlorothiazide 12.5 to 25 mg-Losartan 50 to 100 mg orally once a dayMaximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a dayComments:-A patient whose blood pressure is not adequately controlled with hydrochlorothiazide or losartan monotherapy may be switched to hydrochlorothiazide 12.5 mg-losartan 50 mg orally once a day.-May increase dose if blood pressure remains uncontrolled after about 3 weeks.Use: Treatment of hypertension. This drug is not indicated for initial therapy except when hypertension is severe enough that the benefit of achieving prompt blood pressure control exceeds the risk of initiating combination therapy.SEVERE HYPERTENSION:Initial treatment: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled after 2 to 4 weeks, may initiate maximum dose.Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a dayHYPERTENSION WITH LEFT VENTRICULAR HYPERTROPHY:Initial therapy: Losartan monotherapy; if blood pressure remains uncontrolled, may initiate this drug.Add-on therapy: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled, initiate hydrochlorothiazide 12.5 mg-losartan 100 mg orally once a day, followed by hydrochlorothiazide 25 mg-losartan 100 mg orally once a day, if needed.Use: To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to Black patients.
Warnings
You should not use hydrochlorothiazide and losartan if you are unable to urinate.
Do not use if you are pregnant. Stop using the medicine and tell your doctor right away if you become pregnant.
If you have diabetes, do not use hydrochlorothiazide and losartan together with any medication that contains aliskiren (a blood pressure medicine).
What other drugs will affect Hydrochlorothiazide and losartan
If you also take cholestyramine or colestipol, take your hydrochlorothiazide and losartan dose 4 hours before or 4 to 6 hours after you take the other medicine.
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may affect hydrochlorothiazide and losartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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