Hydrochlorothiazide and metoprolol

Generic name: Hydrochlorothiazide And Metoprolol
Dosage form: oral tablet (25 mg-100 mg; 25 mg-50 mg; 50 mg-100 mg)
Drug class: Beta blockers with thiazides

Usage of Hydrochlorothiazide and metoprolol

Hydrochlorothiazide is a thiazide diuretic (water pill). Metoprolol is a beta-blocker.

Hydrochlorothiazide and metoprolol is a combination medicine used to treat high blood pressure (hypertension).

Hydrochlorothiazide and metoprolol may also be used for purposes not listed in this medication guide.

Hydrochlorothiazide and metoprolol side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Hydrochlorothiazide and metoprolol may cause serious side effects. Call your doctor at once if you have:

bronchospasm (wheezing, chest tightness, trouble breathing);

slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);

blurred vision, tunnel vision, eye pain, or seeing halos around lights;

low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or

low sodium level --headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Common side effects of hydrochlorothiazide and metoprolol may include:

tired feeling; or

stuffy nose, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Hydrochlorothiazide and metoprolol

You should not use this medicine if you are allergic to hydrochlorothiazide or metoprolol, or if you have:

a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), or if your heart cannot pump blood properly;

slow heartbeats that have caused you to faint;

severe or uncontrolled heart failure;

an allergy to sulfa drugs; or

if you are unable to urinate.

Tell your doctor if you have ever had:

congestive heart failure;

slow heartbeats;

blood circulation problems;

asthma or other breathing disorder;

peripheral vascular disease such as Raynaud's syndrome;

diabetes;

a thyroid disorder;

kidney disease (or if you are on dialysis);

pheochromocytoma (tumor of the adrenal gland);

glaucoma;

lupus;

gout; or

high cholesterol or triglycerides.

Tell your doctor if you are pregnant or breastfeeding.

Hydrochlorothiazide and metoprolol is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Hydrochlorothiazide and metoprolol

Usual Adult Dose for Hypertension:

Immediate-release:-Hydrochlorothiazide 25 to 50 mg-Metoprolol 100 to 200 mg orally per day in single or divided dosesExtended-release:-Initial dose: Hydrochlorothiazide 12.5 mg-Metoprolol 25 mg orally once a day-Maximum dose: Hydrochlorothiazide 25 mg-Metoprolol 200 mg orally once a dayComments:-Hydrochlorothiazide doses greater than 50 mg per day are not recommended.-Immediate-release metoprolol (tartrate) may be administered once a day, but lower doses (100 mg) may not maintain a full effect for 24 hours; measure blood pressure near the end of the dosing interval to determine adequate control; larger or more frequent doses may be required.-Extended-release metoprolol (succinate) may be titrated after 2 weeks.-Beta-1 selectivity decreases as the metoprolol dose is increased.

Warnings

You should not use hydrochlorothiazide and metoprolol if you have a serious heart condition such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), slow heartbeats that have caused you to faint, or if your heart cannot pump blood properly.

You should not use hydrochlorothiazide and metoprolol if you are unable to urinate.

Do not stop using this medicine suddenly, even if you feel fine. Stopping suddenly may cause serious or life-threatening heart problems. Follow your doctor's instructions about tapering your dose.

What other drugs will affect Hydrochlorothiazide and metoprolol

Tell your doctor about all your other medicines, especially:

cholestyramine, colestipol;

clonidine;

digoxin;

diltiazem, verapamil;

epinephrine (Epi-Pen);

lithium;

an MAO inhibitor--isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others; or

an NSAID (nonsteroidal anti-inflammatory drug)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), Celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may affect hydrochlorothiazide and metoprolol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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